Skin stem cells

Skin stem cells are multipotent adult stem cells present in the adult skin, which can self-renew and differentiate into different cell lineages of the skin. Skin stem cells are active during skin renewal, which occurs throughout life, and in skin repair after injury.

Latest Research and Reviews

News and Comment

  • News and Views |

    The cancer-suppressive mechanisms underlying a tissue’s response to spontaneous oncogenic mutations during homeostasis are largely unknown. A study now explores how clonal expansion of epidermal stem cells with specific oncogenic mutations might be restricted by their elimination through enforced differentiation.

    • Paola Kuri
    •  & Panteleimon Rompolas
    Nature Cell Biology 20, 1237-1239
  • Comments and Opinion |

    Fiona Watt runs the Centre for Stem Cells and Regenerative Medicine at King’s College London and is an outspoken advocate for women scientists. Since April 2018, she has been on secondment as Executive Chair of the Medical Research Council, one of the major funders of biomedical research in the UK.

    • Fiona M. Watt
  • News and Views |

    During mouse back skin development, subsets of fibroblastic lineages transition from anti-fibrotic Engrailed-1 (En1) negative to pro-fibrotic En1-positive cells. Injuries of adult skin heal with scarring, whereas En1-deficient embryonic fibroblasts have the potential to promote scarless regeneration and repair.

    • Masataka Yokoyama
    •  & Shahin Rafii
    Nature Cell Biology 20, 365-366