Single-channel recording

Single-channel recording is a single-molecule technique that measures the activity of a single membrane channel, usually by means of a patch pipette.

Latest Research and Reviews

  • Research | | open

    The hippocampus is involved both in episodic memory recall and scene processing. Here, the authors show that hippocampal neurons first process scene cues before coordinating memory-guided pattern completion in adjacent entorhinal cortex.

    • Bernhard P. Staresina
    • , Thomas P. Reber
    • , Johannes Niediek
    • , Jan Boström
    • , Christian E. Elger
    •  & Florian Mormann
  • Research | | open

    Magnetoencephalography (MEG) is a non-invasive method of measuring neural activity but the hippocampus and amygdala are difficult to measure with MEG because of their deep localization. Here, the authors show with simultaneous MEG and invasive recordings that hippocampus and amygdala activity can be retrieved from the surface.

    • F. Pizzo
    • , N. Roehri
    • , S. Medina Villalon
    • , A. Trébuchon
    • , S. Chen
    • , S. Lagarde
    • , R. Carron
    • , M. Gavaret
    • , B. Giusiano
    • , A. McGonigal
    • , F. Bartolomei
    • , J. M. Badier
    •  & C. G. Bénar
  • Research | | open

    Electroencephalography (EEG) allows the measurement of electrical signals associated with brain activity, but it is unclear if EEG can accurately measure subcortical activity. Here, the authors show that source dynamics, reconstructed from scalp EEG, correlate with activity recorded from human thalamus and nucleus accumbens.

    • Martin Seeber
    • , Lucia-Manuela Cantonas
    • , Mauritius Hoevels
    • , Thibaut Sesia
    • , Veerle Visser-Vandewalle
    •  & Christoph M. Michel
  • Research | | open

    Place cells and grid cells are known to encode spatial information about an animal’s location relative to the surrounding environment. Here, the authors show that place cells predominantly encode environmental sensory inputs, while grid cell activity reflects a greater influence of physical motion.

    • Guifen Chen
    • , Yi Lu
    • , John A King
    • , Francesca Cacucci
    •  & Neil Burgess
  • Research | | open

    Human Bestrophin1 (hBest1), a calcium-activated chloride channel in retinal pigment epithelium (RPE), is essential for retina physiology. Using electrophysiological and structural approaches, the authors uncover an ATP-dependent activation mechanism of hBest1, and identify an ATP-binding motif.

    • Yu Zhang
    • , Alec Kittredge
    • , Nancy Ward
    • , Changyi Ji
    • , Shoudeng Chen
    •  & Tingting Yang