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Open Access
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Article
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Prevalence of persistent SARS-CoV-2 in a large community surveillance study
Using viral sequence data, individuals with persistent SARS-CoV-2 infections were identified, and had higher odds of self-reporting long COVID, in a large community surveillance study.
- Mahan Ghafari
- , Matthew Hall
- & Katrina Lythgoe
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Article |
High-dimensional characterization of post-acute sequelae of COVID-19
Healthcare data from the US Department of Veterans Affairs are used to characterize the six-month incident sequelae of individuals who survive for at least thirty days after developing COVID-19.
- Ziyad Al-Aly
- , Yan Xie
- & Benjamin Bowe
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Article |
Glucose metabolism links astroglial mitochondria to cannabinoid effects
In mice, persistent activation of mitochondrial cannabinoid receptors in astroglia impairs cellular glucose metabolism and lactate production, leading to an increase in redox stress in neurons and altered behavioural responses.
- Daniel Jimenez-Blasco
- , Arnau Busquets-Garcia
- & Giovanni Marsicano
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Article
| Open Access
Mapping child growth failure across low- and middle-income countries
High-resolution subnational mapping of child growth failure indicators for 105 low- and middle-income countries between 2000 and 2017 shows that, despite considerable progress, substantial geographical inequalities still exist in some countries.
- Damaris K. Kinyoki
- , Aaron E. Osgood-Zimmerman
- & Simon I. Hay
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Article |
Structure-based discovery of opioid analgesics with reduced side effects
Computational docking to the the μ-opioid-receptor identifies PZM21, a novel selective biased agonist that generates substantial affective analgesia in mice without altering respiration or inducing drug reinforcement.
- Aashish Manglik
- , Henry Lin
- & Brian K. Shoichet
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Outlook |
Psoriasis uncovered
Science is finally getting to grips with this enigmatic autoimmune disease.
- James Mitchell Crow
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Outlook |
Therapeutics: Silencing psoriasis
The latest drugs hold fantastic promise for people with severe psoriasis. But where are the treatment options for the far larger number with less serious cases?
- James Mitchell Crow
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Outlook |
Psychodermatology: An emotional response
As the link between stress and psoriasis flare-ups becomes clearer, it seems the most vulnerable patients require a new type of treatment.
- Sarah DeWeerdt
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Outlook |
Q&A: Under their skin
Psoriasis can have a profound impact on patients' emotional and social lives. Christopher Griffiths, a dermatologist at the University of Manchester in the United Kingdom, discusses the disease's psychological fallout and its links with stress.
- Christopher Griffiths
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Outlook |
Perspective: Don't be superficial
Severe psoriasis carries cardiovascular risks. Dermatologists should consider more than just patients' outer layers, argues Henning Boehncke.
- Wolf-Henning Boehncke
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Outlook |
Genetics: Deep exploration
Recent discoveries are redefining the role of the immune system in psoriasis, and may help to unravel the mystery of the disease's origins.
- Ken Garber
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Outlook |
Microbiome: The surface brigade
Our skin is home to thousands of species of bacteria — and when these microscopic societies are disrupted, skin infections can arise.
- Bijal Trivedi
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Outlook |
Immunology: A many layered thing
No mere passive barrier, the skin is being revealed to be an active part of the immune system. Researchers are now starting to understand its role in driving psoriasis.
- Claire Ainsworth
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News |
Global survey reveals impact of disability
Study tracks changes in life expectancy and health burdens.
- Declan Butler
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Outlook |
Technology: Dancing with robots
High-tech gadgets such as sensors that detect falls and robots that can fetch items are helping people stay independent and safe into their later years.
- Neil Savage
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Outlook |
Diagnosis: To catch a killer
The first symptoms of COPD can be subtle, so the disease often goes undiagnosed. Researchers are searching for ways to detect the disease and to identify those most at risk.
- Cassandra Willyard
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Outlook |
Health impact: Breathless
COPD is one of the world's biggest killers, but awareness is low, diagnosis is often missed, and in many countries the extent of the problem is not even well-documented.
- Amber Dance
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News |
Rabbits show their pain
The extension of 'grimace scales' highlights their growing role in research.
- Daniel Cressey
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Letter |
An oxygen-regulated switch in the protein synthesis machinery
Hypoxia activates a translation initiation pathway that escapes global inhibition of protein synthesis.
- James Uniacke
- , Chet E. Holterman
- & Stephen Lee
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Letter |
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
- Christian M. Metallo
- , Paulo A. Gameiro
- & Gregory Stephanopoulos
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Research Highlights |
Vertigo in the MRI machine
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Letter |
Homeostatic response to hypoxia is regulated by the N-end rule pathway in plants
- Daniel J. Gibbs
- , Seung Cho Lee
- & Michael J. Holdsworth
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Letter |
Oxygen sensing in plants is mediated by an N-end rule pathway for protein destabilization
- Francesco Licausi
- , Monika Kosmacz
- & Joost T. van Dongen
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Research Highlights |
Switch the pain for an itch
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News |
Antibodies linked to long-term Lyme symptoms
Researchers find molecules that might mark elusive syndrome.
- Amy Maxmen
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News |
Chronic fatigue syndrome: life after XMRV
As doubts about the retrovirus reach fever pitch, scientists focus on alternative directions for the field.
- Ewen Callaway
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Article |
Loss-of-function mutations in sodium channel Nav1.7 cause anosmia
- Jan Weiss
- , Martina Pyrski
- & Frank Zufall
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A population-specific HTR2B stop codon predisposes to severe impulsivity
Impulsive behaviour characterizes several psychiatric diseases and violent behaviour but its origins are complex. Here, exon sequencing focused on fourteen serotonin- and dopamine-related genes identified a mutation in HTR2B, which was associated with psychiatric diseases marked by impulsivity in a Finnish population. The role of this serotonin receptor in impulsivity is further supported by the knockout mouse phenotype.
- Laura Bevilacqua
- , Stéphane Doly
- & David Goldman
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Outlook |
Secrets of the shaking palsy
Parkinson's disease might have much in common with Alzheimer's disease, prion diseases and other protein-aggregation disorders. Jim Schnabel investigates.
- Jim Schnabel
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Books & Arts |
Overcoming agony
A broad account of the science of pain offers hope to patients but highlights how the culture of medicine needs to change, explains Lucy Odling-Smee.
- Lucy Odling-Smee
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Research Highlights |
Biology: Colour-blind
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Research Highlights |
Genetics: Two strikes
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News |
Genetic basis for stuttering identified
Mutations found in genes responsible for directing enzymes to their cellular destination.
- Janet Fang
Crym-positive striatal astrocytes gate perseverative behaviour
Mice may make morphine