Signal transduction

Latest Research and Reviews

News and Comment

  • News and Views |

    Activation of STING requires its translocation from the endoplasmic reticulum (ER) through the Golgi to vesicles, but the mechanisms that control its localization have been unclear. The ER calcium sensor STIM1 acts as an ER-retention factor that anchors STING on the ER and limits STING signaling.

    • Jianjun Wu
    •  & Nan Yan
    Nature Immunology 20, 112-114
  • News and Views |

    A new model proposes that an applied force allows the co-receptor CD8 and the kinase Lck to selectively stabilize TCR interactions with negatively selecting ligands, but not those with positively selecting ligands, during the negative selection of self-reactive thymocytes.

    • Omer Dushek
    •  & Michael L. Dustin
    Nature Immunology 19, 1280-1281
  • Comments and Opinion |

    G protein coupled receptors (GPCRs) transmit a variety of signals, mostly by engaging G proteins, but G protein-independent signalling through arrestins has also been demonstrated. Based on recent experimental evidence, Gutkind and Kostenis argue that arrestins serve as important signal modulators instead of as independent signal transducers.

    • J. Silvio Gutkind
    •  & Evi Kostenis
  • News and Views |

    T cell activation is ‘digital’: exhaustive single-cell analysis shows that only the proportion of cells that cross the activation threshold is reduced when the affinity of the TCR for its ligand is reduced.

    • Renu Balyan
    • , Joanna Brzostek
    •  & Nicholas R. J. Gascoigne
    Nature Immunology 19, 797-799