Scleroproteins are proteins that form long rod-like filaments, which generally serve as a storage unit or in a structural capacity, as in collagen. Because of the filamentous nature of scleroprotein assemblies, they are insoluble in aqueous solutions and prone to aggregation.

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    Cells package proteins into vesicles for secretion to the extracellular milieu. A study has now identified an enzyme that modifies the packaging machinery to encapsulate unusually large proteins, such as collagen. See Article p.495

    • David J. Stephens
    Nature 482, 474–475