Schwann cell

Definition

Latest Research and Reviews

  • Reviews |

    Research into the mechanisms of diabetic neuropathy have focused on neurons, but evidence is accumulating that Schwann cells have a central role. In this Review, the authors consider how Schwann cell dysfunction and the interactions of these cells with neurons and microvessels contribute to the pathogenesis of neuropathy in diabetes.

    • Nádia P. Gonçalves
    • , Christian B. Vægter
    • , Henning Andersen
    • , Leif Østergaard
    • , Nigel A. Calcutt
    •  & Troels S. Jensen
  • Research | | open

    Brügger et al. identify part of the molecular machinery that controls Schwann cell development after peripheral nerve injury. Inhibiting HDAC1/2 early after injury enhances nerve regeneration and promotes functional recovery.

    • Valérie Brügger
    • , Mert Duman
    • , Maëlle Bochud
    • , Emmanuelle Münger
    • , Manfred Heller
    • , Sophie Ruff
    •  & Claire Jacob
  • Research |

    By studying a severe neuropathy in mice, Quintes, Brinkmann et al. demonstrate that the nuclear zinc-finger protein Zeb2 (Sip1) is essential for Schwann cell differentiation and myelin synthesis. Since Zeb2-deficient Schwann cells continuously express repressors of lineage progression, ‘inhibiting the inhibitors’ emerges as a new principle of peripheral myelination control.

    • Susanne Quintes
    • , Bastian G Brinkmann
    • , Madlen Ebert
    • , Franziska Fröb
    • , Theresa Kungl
    • , Friederike A Arlt
    • , Victor Tarabykin
    • , Danny Huylebroeck
    • , Dies Meijer
    • , Ueli Suter
    • , Michael Wegner
    • , Michael W Sereda
    •  & Klaus-Armin Nave
    Nature Neuroscience 19, 1050–1059
  • Research |

    This study shows that the transcriptional regulator Zeb2 is required for the onset of peripheral myelination and remyelination. Zeb2 recruits HDAC1–HDAC2–NuRD co-repressor complexes to antagonize inhibitory effectors including Notch, while activating promyelinogenic factors. A Mowat-Wilson syndrome–associated ZEB2 mutation disrupting HDAC–NuRD interaction abolishes Zeb2 activity for Schwann cell differentiation.

    • Lai Man Natalie Wu
    • , Jincheng Wang
    • , Andrea Conidi
    • , Chuntao Zhao
    • , Haibo Wang
    • , Zachary Ford
    • , Liguo Zhang
    • , Christiane Zweier
    • , Brian G Ayee
    • , Patrice Maurel
    • , An Zwijsen
    • , Jonah R Chan
    • , Michael P Jankowski
    • , Danny Huylebroeck
    •  & Q Richard Lu
    Nature Neuroscience 19, 1060–1072
  • Research |

    Cells respond to mechanical signals during development and after injury. Poitelon et al. report for the first time that myelin-forming glia activate the Hippo pathway effectors Yap and Taz in response to mechanical stimuli, and that they are required for Schwann cell development and myelination in vivo.

    • Yannick Poitelon
    • , Camila Lopez-Anido
    • , Kathleen Catignas
    • , Caterina Berti
    • , Marilena Palmisano
    • , Courtney Williamson
    • , Dominique Ameroso
    • , Kansho Abiko
    • , Yoonchan Hwang
    • , Alex Gregorieff
    • , Jeffrey L Wrana
    • , Mohammadnabi Asmani
    • , Ruogang Zhao
    • , Fraser James Sim
    • , Lawrence Wrabetz
    • , John Svaren
    •  & Maria Laura Feltri
    Nature Neuroscience 19, 879–887

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