RNA modification

Definition

RNA modifications are changes to the chemical composition of ribonucleic acid (RNA) molecules post-synthesis that have the potential to alter function or stability. An example of RNA modification is the addition of a methylated guanine nucleotide “cap” to the 5’-end of messenger RNAs (mRNAs).

Featured

Latest Research and Reviews

  • Research |

    A high-resolution structure of the human ribosome determined by cryo-electron microscopy visualizes numerous RNA modifications that are concentrated at functional sites with an extended shell, and suggests the possibility of designing more specific ribosome-targeting drugs.

    • S. Kundhavai Natchiar
    • , Alexander G. Myasnikov
    • , Hanna Kratzat
    • , Isabelle Hazemann
    •  & Bruno P. Klaholz
  • Research |

    Transcriptome-wide mapping of N1-methyladenosine (m1A) at single-nucleotide resolution reveals m1A to be scarce in cytoplasmic mRNA, to inhibit translation, and to be highly dynamic at a single site in a mitochondrial mRNA.

    • Modi Safra
    • , Aldema Sas-Chen
    • , Ronit Nir
    • , Roni Winkler
    • , Aharon Nachshon
    • , Dan Bar-Yaacov
    • , Matthias Erlacher
    • , Walter Rossmanith
    • , Noam Stern-Ginossar
    •  & Schraga Schwartz
    Nature 551, 251–255
  • Research |

    TUT4 and TUT7 mediate 3′ uridylation of mRNA transcripts, preferentially those with short poly(A) tails; in the absence of TUT4 and TUT7, oocytes cannot mature and female mice are infertile.

    • Marcos Morgan
    • , Christian Much
    • , Monica DiGiacomo
    • , Chiara Azzi
    • , Ivayla Ivanova
    • , Dimitrios M. Vitsios
    • , Jelena Pistolic
    • , Paul Collier
    • , Pedro N. Moreira
    • , Vladimir Benes
    • , Anton J. Enright
    •  & Dónal O’Carroll
    Nature 548, 347–351
  • Research |

    In echinoderm mitochondria, the codon AAA encodes asparagine instead of lysine. A newly identified nucleoside modification, hydroxy-N6-threonylcarbamoyladenosine (ht6A), is found adjacent to the anticodon in mt-tRNALys and prevents mt-tRNALys from misreading AAA as lysine.

    • Asuteka Nagao
    • , Mitsuhiro Ohara
    • , Kenjyo Miyauchi
    • , Shin-ichi Yokobori
    • , Akihiko Yamagishi
    • , Kimitsuna Watanabe
    •  & Tsutomu Suzuki
  • Research | | open

    N 6-methyladenosine (m6A) is a conserved RNA modification that has recently emerged as an important regulator of messenger RNA processing and activity. Here, the authors provide evidence that m6A pathway facilitates female-specific splicing of Sxl, regulating sex determination in Drosophila.

    • Lijuan Kan
    • , Anya V. Grozhik
    • , Jeffrey Vedanayagam
    • , Deepak P. Patil
    • , Nan Pang
    • , Kok-Seong Lim
    • , Yi-Chun Huang
    • , Brian Joseph
    • , Ching-Jung Lin
    • , Vladimir Despic
    • , Jian Guo
    • , Dong Yan
    • , Shu Kondo
    • , Wu-Min Deng
    • , Peter C. Dedon
    • , Samie R. Jaffrey
    •  & Eric C. Lai

News and Comment