RNA editing

Definition

RNA editing is the process by which ribonucleic acid (RNA) molecules are enzymatically modified post synthesis on specific nucleosides. Examples of RNA editing include pseudouridylation (the isomerization of uridine residues) and deamination (removal of an amine group from cytidine to give rise to uridine, or C-to-U editing).

Latest Research and Reviews

  • Research | | open

    Environmental adaptation is generally studied at the genomic level, but it may also be driven by transcriptional processes. Here, the authors investigate variation in gene expression and RNA editing across diverging populations of Drosophila melanogaster from two microclimates.

    • Arielle L. Yablonovitch
    • , Jeremy Fu
    • , Kexin Li
    • , Simpla Mahato
    • , Lin Kang
    • , Eugenia Rashkovetsky
    • , Abraham B. Korol
    • , Hua Tang
    • , Pawel Michalak
    • , Andrew C. Zelhof
    • , Eviatar Nevo
    •  & Jin Billy Li
  • Research |

    Using the GTEx data and others, a comprehensive analysis of adenosine-to-inosine RNA editing in mammals is presented; targets of the various ADAR enzymes are identified, as are several potential regulators of editing, such as AIMP2.

    • Meng How Tan
    • , Qin Li
    • , Raghuvaran Shanmugam
    • , Robert Piskol
    • , Jennefer Kohler
    • , Amy N. Young
    • , Kaiwen Ivy Liu
    • , Rui Zhang
    • , Gokul Ramaswami
    • , Kentaro Ariyoshi
    • , Ankita Gupte
    • , Liam P. Keegan
    • , Cyril X. George
    • , Avinash Ramu
    • , Ni Huang
    • , Elizabeth A. Pollina
    • , Dena S. Leeman
    • , Alessandra Rustighi
    • , Y. P. Sharon Goh
    • , GTEx Consortium
    • , Ajay Chawla
    • , Giannino Del Sal
    • , Gary Peltz
    • , Anne Brunet
    • , Donald F. Conrad
    • , Charles E. Samuel
    • , Mary A. O’Connell
    • , Carl R. Walkley
    • , Kazuko Nishikura
    •  & Jin Billy Li
    Nature 550, 249–254
  • Reviews |

    This Review discusses the roles of deregulated RNA processing, including RNA methylation, RNA editing, RNA splicing and RNA binding protein activity, in cancer stem cells and highlights the potential of these events as biomarkers and therapeutic targets.

    • Qingfei Jiang
    • , Leslie A. Crews
    • , Frida Holm
    •  & Catriona H. M. Jamieson
    Nature Reviews Cancer 17, 381–392
  • Research |

    In stressed cells, the ADAR1p110 isoform is phosphorylated and translocated from the nucleus to the cytoplasm, where it protects transcripts with 3′-UTR dsRNA structures from Staufen1-mediated decay, thus suppressing cellular apoptosis.

    • Masayuki Sakurai
    • , Yusuke Shiromoto
    • , Hiromitsu Ota
    • , Chunzi Song
    • , Andrew V Kossenkov
    • , Jayamanna Wickramasinghe
    • , Louise C Showe
    • , Emmanuel Skordalakes
    • , Hsin-Yao Tang
    • , David W Speicher
    •  & Kazuko Nishikura

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