Rhesus macaque

The rhesus macaque (Macaca mulatta) is an Asian Old World monkey used in biomedical research due to its closeness to humans and to the ease of rearing the animal in captivity.

Latest Research and Reviews

  • Research | | open

    Human embryonic stem cells can be differentiated in vitro into primordial germ cell-like cells (PGCLCs) that resemble early primordial germ cells (PGCs). Here the authors transplant PGCLCs generated from rhesus macaque iPSCs into mouse and rhesus macaque seminiferous tubules, which matures these into late PGCs and spermatogonia-like cells.

    • Enrique Sosa
    • , Di Chen
    • , Ernesto J. Rojas
    • , Jon D. Hennebold
    • , Karen A. Peters
    • , Zhuang Wu
    • , Truong N. Lam
    • , Jennifer M. Mitchell
    • , Meena Sukhwani
    • , Ramesh C. Tailor
    • , Marvin L. Meistrich
    • , Kyle E. Orwig
    • , Gunapala Shetty
    •  & Amander T. Clark
  • Research |

    Zika virus infection during pregnancy is associated with an increased rate of fetal loss in nonhuman primates, as reported in this multicenter analysis.

    • Dawn M. Dudley
    • , Koen K. Van Rompay
    • , Lark L. Coffey
    • , Amir Ardeshir
    • , Rebekah I. Keesler
    • , Eliza Bliss-Moreau
    • , Peta L. Grigsby
    • , Rosemary J. Steinbach
    • , Alec J. Hirsch
    • , Rhonda P. MacAllister
    • , Heidi L. Pecoraro
    • , Lois M. Colgin
    • , Travis Hodge
    • , Daniel N. Streblow
    • , Suzette Tardif
    • , Jean L. Patterson
    • , Manasi Tamhankar
    • , Maxim Seferovic
    • , Kjersti M. Aagaard
    • , Claudia Sánchez-San Martín
    • , Charles Y. Chiu
    • , Antonito T. Panganiban
    • , Ronald S. Veazey
    • , Xiaolei Wang
    • , Nicholas J. Maness
    • , Margaret H. Gilbert
    • , Rudolf P. Bohm
    • , Kristina M. Adams Waldorf
    • , Michael Gale Jr
    • , Lakshmi Rajagopal
    • , Charlotte E. Hotchkiss
    • , Emma L. Mohr
    • , Saverio V. Capuano III
    • , Heather A. Simmons
    • , Andres Mejia
    • , Thomas C. Friedrich
    • , Thaddeus G. Golos
    •  & David H. O’Connor
    Nature Medicine 24, 1104-1107
  • Research | | open

    Caloric restriction (CR) delays ageing of model organisms, but whether it works in nonhuman primates has been controversial. Here, the authors pool and reanalyse data from two long-running CR primate studies, concluding that moderate CR indeed improves health and survival of rhesus monkeys.

    • Julie A. Mattison
    • , Ricki J. Colman
    • , T. Mark Beasley
    • , David B. Allison
    • , Joseph W. Kemnitz
    • , George S. Roth
    • , Donald K. Ingram
    • , Richard Weindruch
    • , Rafael de Cabo
    •  & Rozalyn M. Anderson
  • Research | | open

    The amygdala in the medial temporal lobe of the human and non-human primate brain is known to process salient social stimuli and to mediate threat discrimination. Here, Dal Monte et al. show that rhesus monkeys with amygdala lesions have deficits in detecting threat signals and directing attention to the eye region of a conspecific's face.

    • Olga Dal Monte
    • , Vincent D. Costa
    • , Pamela L. Noble
    • , Elisabeth A. Murray
    •  & Bruno B. Averbeck

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