Rhesus macaque

Definition

The rhesus macaque (Macaca mulatta) is an Asian Old World monkey used in biomedical research due to its closeness to humans and to the ease of rearing the animal in captivity.

Latest Research and Reviews

  • Research | | open

    Caloric restriction (CR) delays ageing of model organisms, but whether it works in nonhuman primates has been controversial. Here, the authors pool and reanalyse data from two long-running CR primate studies, concluding that moderate CR indeed improves health and survival of rhesus monkeys.

    • Julie A. Mattison
    • , Ricki J. Colman
    • , T. Mark Beasley
    • , David B. Allison
    • , Joseph W. Kemnitz
    • , George S. Roth
    • , Donald K. Ingram
    • , Richard Weindruch
    • , Rafael de Cabo
    •  & Rozalyn M. Anderson
  • Research | | open

    The amygdala in the medial temporal lobe of the human and non-human primate brain is known to process salient social stimuli and to mediate threat discrimination. Here, Dal Monte et al. show that rhesus monkeys with amygdala lesions have deficits in detecting threat signals and directing attention to the eye region of a conspecific's face.

    • Olga Dal Monte
    • , Vincent D. Costa
    • , Pamela L. Noble
    • , Elisabeth A. Murray
    •  & Bruno B. Averbeck
  • Research |

    Protective efficacy of novel vaccine candidates in rhesus monkeys opens new paths for the development of an HIV-1 vaccine.

    • Dan H. Barouch
    • , Jinyan Liu
    • , Hualin Li
    • , Lori F. Maxfield
    • , Peter Abbink
    • , Diana M. Lynch
    • , M. Justin Iampietro
    • , Adam SanMiguel
    • , Michael S. Seaman
    • , Guido Ferrari
    • , Donald N. Forthal
    • , Ilnour Ourmanov
    • , Vanessa M. Hirsch
    • , Angela Carville
    • , Keith G. Mansfield
    • , Donald Stablein
    • , Maria G. Pau
    • , Hanneke Schuitemaker
    • , Jerald C. Sadoff
    • , Erik A. Billings
    • , Mangala Rao
    • , Merlin L. Robb
    • , Jerome H. Kim
    • , Mary A. Marovich
    • , Jaap Goudsmit
    •  & Nelson L. Michael
    Nature 482, 89–93
  • Research |

    In this paper, the authors present evidence for spatially overlapping populations of neurons representing positive and negative subjective value in the primate pregenual anterior cingulate cortex (pACC) during an approach-avoidance task. However, in one subzone of the pACC, negative coding predominated, and microstimulation in this subzone increased negative decision-making, a bias that was blocked by anti-anxiety drug treatment.

    • Ken-ichi Amemori
    •  & Ann M Graybiel
    Nature Neuroscience 15, 776–785