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GPCRs are key regulators of vascular functions. By analysing single-cell GPCRs expression in vascular smooth muscle and endothelial cells from healthy and diseased murine vessels, Kaur et al. show that GPCR expression is highly heterogeneous in all cell types and that disease causes GPCR repertoire changes depending on cell type and vascular localization.
Numerous studies have suggested the utility of non-invasive molecular biomarkers to monitor recipients of kidney transplants. A new correlation-based algorithm using stepwise analysis of gene expression data from peripheral blood samples, claiming to detect subclinical, and predict clinical acute allograft rejection, requires corroboration before testing in prospective validation studies.