Retromer

Definition

The retromer is a protein complex containing sorting nexin (Snx) and vacuolar protein sorting (Vps) components. It has an essential role in recycling cargo molecules from endosomes to the trans-Golgi network, and mediates certain endosome-to-plasma membrane recycling events.

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Latest Research and Reviews

News and Comment

  • News and Views |

    Recycling from endosomes to the plasma membrane is an important step in cell homeostasis. The retromer/SNX27/WASH complex recycles numerous receptors, but key ones are still unaccounted for. Now a related conserved heterotrimer, called retriever, has been identified that, together with SNX17, the CCC complex and WASH, mediates the recycling of α5β1 integrins.

    • Catherine Rabouille
    Nature Cell Biology 19, 1144–1146
  • Research Highlights |

    The protein complex retromer mediates the recycling of cell surface receptors that are essential for 'corpse clearance' in roundworms

    • Felix Cheung
  • News and Views |

    Parathyroid hormone analog PTH(1–34), used clinically to treat osteoporosis, forms a stable complex with its receptor and prolongs cAMP production even after internalization and recruitment to endosomes. New data suggest this signaling cascade is stimulated by β-arrestins and terminated by retromer.

    • Jan R T van Weering
    •  & Peter J Cullen