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The retina is a layered structure that lines the inner surface of the eye. It consists of layers of neurons: light-sensitive photoreceptor cells, bipolar cells, horizontal cells, amacrine cells and retinal ganglion cells, which transmit the visual information to other parts of the visual system along the optic nerve.
Das and colleagues develop and evaluate a parallel discriminator generative adversarial network (P-GAN) for improved in-vivo imaging of retinal cellular structures. The P-GAN network improves retinal pigment epithelium contrast 3.5-fold and the overall throughput 99-fold.
How the spatial distribution of synapses relates to the subcellular integration and transmission of signals is not fully understood. Here authors combine functional and connectomic analysis to map the subcellular flow of information in retinal amacrine cells.