Restriction factors

Restriction factors are anti-viral proteins that are produced in the host and counteract or 'restrict' viral replication. These proteins are considered a first line of defence against viruses.

Latest Research and Reviews

  • Research | | open

    The accessory lentiviral protein X (Vpx) of the SIVsmm/mac and HIV-2 lineage targets the host-restriction factor SAMHD1 for proteasomal degradation. Here, the authors show that host PIM kinase-mediated phosphorylation of Vpx stabilizes its interaction with SAMHD1, suggesting PIM as potential antiviral targets.

    • Kei Miyakawa
    • , Satoko Matsunaga
    • , Masaru Yokoyama
    • , Masako Nomaguchi
    • , Yayoi Kimura
    • , Mayuko Nishi
    • , Hirokazu Kimura
    • , Hironori Sato
    • , Hisashi Hirano
    • , Tomohiko Tamura
    • , Hirofumi Akari
    • , Tomoyuki Miura
    • , Akio Adachi
    • , Tatsuya Sawasaki
    • , Naoki Yamamoto
    •  & Akihide Ryo
  • Research |

    Using a small interfering RNA-based library screening in interferon-treated cells, the authors identified human tripartite-containing motif 5α as potent restriction factor that inhibits HIV-1 DNA synthesis and infection in a capsid- and immunoproteasome-dependent manner.

    • Jose M. Jimenez-Guardeño
    • , Luis Apolonia
    • , Gilberto Betancor
    •  & Michael H. Malim
    Nature Microbiology 4, 933-940
  • Research |

    Proteomic analysis coupled to RNA interference screening identifies the host exon–junction complex recycling factor partner of Y14 and mago (PYM1) as antiviral against three flaviruses, whose capsids interact with PYM1 and interfere with its ability to trigger nonsense-mediated decay-dependent degradation of viral RNA.

    • Minghua Li
    • , Jeffrey R. Johnson
    • , Billy Truong
    • , Grace Kim
    • , Nathan Weinbren
    • , Mark Dittmar
    • , Priya S. Shah
    • , John Von Dollen
    • , Billy W. Newton
    • , Gwendolyn M. Jang
    • , Nevan J. Krogan
    • , Sara Cherry
    •  & Holly Ramage
    Nature Microbiology 4, 985-995
  • Research | | open

    Ghizlane Maarifi et al. demonstrate that a nuclear pore component, RanBP2, SUMOylates the retroviral restriction factor TRIM5α to promote its antiviral activity. This study suggests an unexpected role of the nuclear pore for regulating anti-viral innate immunity.

    • Ghizlane Maarifi
    • , Juliette Fernandez
    • , Débora M. Portilho
    • , Aude Boulay
    • , Jacques Dutrieux
    • , Stéphane Oddos
    • , Gillian Butler-Browne
    • , Sébastien Nisole
    •  & Nathalie J. Arhel
  • Research |

    Viral protein X from HIV-2/SIV targets the HUSH (TASOR, MPP8 and periphilin) complex for proteasomal degradation through recruitment of the DCAF1 ubiquitin ligase adaptor, enabling reactivation of latent proviruses.

    • Ghina Chougui
    • , Soundasse Munir-Matloob
    • , Roy Matkovic
    • , Michaël M Martin
    • , Marina Morel
    • , Hichem Lahouassa
    • , Marjorie Leduc
    • , Bertha Cecilia Ramirez
    • , Lucie Etienne
    •  & Florence Margottin-Goguet
    Nature Microbiology 3, 891-897

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