Regeneration

Definition

Regeneration is the process by which lost or damaged tissues, organs or limbs are re-formed from the remaining tissue. During regeneration, adult stem cells and/or progenitor cells differentiate to replace the missing tissue, although in some instances differentiated cells can also participate in the regeneration by proliferation or transdifferentiation.

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Latest Research and Reviews

  • Research |

    Autologous transgenic epidermal stem cell cultures are used to reconstitute almost the entire epidermis of a patient with severe junctional epidermolysis bullosa.

    • Tobias Hirsch
    • , Tobias Rothoeft
    • , Norbert Teig
    • , Johann W. Bauer
    • , Graziella Pellegrini
    • , Laura De Rosa
    • , Davide Scaglione
    • , Julia Reichelt
    • , Alfred Klausegger
    • , Daniela Kneisz
    • , Oriana Romano
    • , Alessia Secone Seconetti
    • , Roberta Contin
    • , Elena Enzo
    • , Irena Jurman
    • , Sonia Carulli
    • , Frank Jacobsen
    • , Thomas Luecke
    • , Marcus Lehnhardt
    • , Meike Fischer
    • , Maximilian Kueckelhaus
    • , Daniela Quaglino
    • , Michele Morgante
    • , Silvio Bicciato
    • , Sergio Bondanza
    •  & Michele De Luca
    Nature 551, 327–332
  • Research | | open

    Mesodermal iPSC-derived progenitors (MiPs) can regenerate both skeletal and cardiac muscle. Here, the authors show that a microRNA cocktail stimulates skeletal muscle differentiation and that human MiPs can engraft into striated muscle in mice.

    • Giorgia Giacomazzi
    • , Bryan Holvoet
    • , Sander Trenson
    • , Ellen Caluwé
    • , Bojana Kravic
    • , Hanne Grosemans
    • , Álvaro Cortés-Calabuig
    • , Christophe M. Deroose
    • , Danny Huylebroeck
    • , Said Hashemolhosseini
    • , Stefan Janssens
    • , Elizabeth McNally
    • , Mattia Quattrocelli
    •  & Maurilio Sampaolesi
  • Research | | open

    Organ regeneration by transplantation of ESC/iPSC-derived tissues is a promising but still challenging approach. Here Lin et al. show that liver damage caused by a chemical insult induces not only fibrosis but also Lgr5+ cell expansion that can be further promoted by treatment with HGF/R-spondin1.

    • Yuan Lin
    • , Zhe-Ping Fang
    • , Hong-Juan Liu
    • , Li-Jing Wang
    • , Zhiqiang Cheng
    • , Na Tang
    • , Tingting Li
    • , Tengfei Liu
    • , Hai-Xiong Han
    • , Guangwen Cao
    • , Li Liang
    • , Yan-Qing Ding
    •  & Wei-Jie Zhou
  • Research |

    Cruz-Acuña et al. develop synthetic hydrogels that support the generation and expansion of viable human intestinal organoids from pluripotent stem cells and can be used as injectable vehicles for organoid engraftment and wound healing.

    • Ricardo Cruz-Acuña
    • , Miguel Quirós
    • , Attila E. Farkas
    • , Priya H. Dedhia
    • , Sha Huang
    • , Dorothée Siuda
    • , Vicky García-Hernández
    • , Alyssa J. Miller
    • , Jason R. Spence
    • , Asma Nusrat
    •  & Andrés J. García
    Nature Cell Biology 19, 1326–1335

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