Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Regeneration and repair in the nervous system is a process by which damaged tissue undergoes regrowth or renewal, leading to eventual restoration of nervous system function. This process happens more readily with axons, synapses, neurons and glia in the peripheral nervous system.
Various neurostimulation techniques are being explored for the treatment of physical impairments in people with stroke. This Review summarizes our current knowledge of the techniques that are now in clinical use or have reached the stage of pivotal trials alongside emerging techniques and highlights the need for further studies.
Glial cells and their crosstalk after injury are crucial for brain regeneration. Here, the authors show the spatial, temporal, and single-cell responses of glial cells after injury and identify shared pathways controlling glial reactivity.
In the CELLTOP Phase I trial, stem cells were harvested from patients with spinal cord injury and injected into their central nervous system after processing. The procedure was safe, with no reported serious adverse events during the 2-year follow-up period.
How the neighboring cells contribute to the survival and functions of neuronal cells remains elusive. Here, authors identified the cell-cell interactions between retinal ganglion cells (RGCs) and other cells after RGC injury and discovered the μ-opioid receptor promotes RGC resilience.
A study in mice identifies formin 2 as a regulator of axon regeneration and a potential target for promoting nerve repair after peripheral nerve injury.
An article in Science Advances reports a biohybrid neural interface device that integrates a cell layer on a microelectrode array, achieving high-resolution mapping of neuronal inputs and restoration of nerve function.
