Recombinant vaccine articles from across Nature Portfolio

A controversial study in which researchers generated an infectious horsepox virus using synthetic DNA and reverse genetics was recently reported.

A cancer vaccine is streamlined by identifying a small set of potent immunogens in a tumor cDNA library.

No approved vaccine is currently available against hepatitis E virus (HEV), which can cause acute hepatitis E. A large-scale phase III study involving more than 100,000 Chinese adults has reported that the recombinant HEV vaccine, HEV 239, prevented acute hepatitis E with a vaccine efficacy of 94–100%.