Reactive precursors

Definition

Reactive precursors are substances that exist as intermediates in multi-step reaction processes, such as in the synthesis of complex nanoparticles.

Latest Research and Reviews

  • Research | | open

    It has been proposed that stacking antiaromatic molecules can build three-dimensional aromaticity, but this claim has lacked experimental validation. Here the authors report that π–π stacked antiaromatic porphyrins display significantly reduced antiaromaticity in solid state and in solution.

    • Ryo Nozawa
    • , Hiroko Tanaka
    • , Won-Young Cha
    • , Yongseok Hong
    • , Ichiro Hisaki
    • , Soji Shimizu
    • , Ji-Young Shin
    • , Tim Kowalczyk
    • , Stephan Irle
    • , Dongho Kim
    •  & Hiroshi Shinokubo
  • Protocols |

    Aryl iodides are useful precursors in the synthesis of compounds used, for example, in the pharmaceutical and electronics industries. This protocol describes a transition metal–free, photo-induced aromatic Finkelstein iodination reaction.

    • Lu Li
    • , Wenbo Liu
    • , Xiaoyue Mu
    • , Zetian Mi
    •  & Chao-Jun Li
    Nature Protocols 11, 1948–1954
  • Protocols |

    In this protocol from Bode and co-workers, peptide fragments containing N-terminal 5-oxaproline and a C-terminal α-ketoacids are prepared by solid-phase peptide synthesis. KAHA ligation results in the formation of medium-sized proteins.

    • Thibault J Harmand
    • , Claudia E Murar
    •  & Jeffrey W Bode
    Nature Protocols 11, 1130–1147
  • Protocols |

    Many solid tumors contain an aggressive hypoxic region that is difficult to treat. This protocol describes how to prepare bioreductive prodrugs that are biologically inactive until they are converted to an active drug by enzymatic reduction in hypoxia.

    • Liam J O'Connor
    • , Cindy Cazares-Körner
    • , Jaideep Saha
    • , Charles N G Evans
    • , Michael R L Stratford
    • , Ester M Hammond
    •  & Stuart J Conway
    Nature Protocols 11, 781–794

News and Comment

  • News and Views |

    Free radicals are notorious for unselective coupling reactions; however, the coupling of free radicals generated from acyl tellurides has now been shown to form C–C bonds with remarkable fidelity, which enables easy one-step assembly of densely oxygenated natural product motifs.

    • Wenhao Zhang
    •  & Ang Li
    Nature Chemistry 9, 198–199