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This protocol describes the diastereoselective approach for the synthesis of complex, acyclic molecular architectures possessing two stereogenic centers in a 1,4 relationship based on a zirconium-promenade reaction using the Negishi reagent.
It has been proposed that stacking antiaromatic molecules can build three-dimensional aromaticity, but this claim has lacked experimental validation. Here the authors report that π–π stacked antiaromatic porphyrins display significantly reduced antiaromaticity in solid state and in solution.
Aryl iodides are useful precursors in the synthesis of compounds used, for example, in the pharmaceutical and electronics industries. This protocol describes a transition metal–free, photo-induced aromatic Finkelstein iodination reaction.
In this protocol from Bode and co-workers, peptide fragments containing N-terminal 5-oxaproline and a C-terminal α-ketoacids are prepared by solid-phase peptide synthesis. KAHA ligation results in the formation of medium-sized proteins.
Many solid tumors contain an aggressive hypoxic region that is difficult to treat. This protocol describes how to prepare bioreductive prodrugs that are biologically inactive until they are converted to an active drug by enzymatic reduction in hypoxia.
Free radicals are notorious for unselective coupling reactions; however, the coupling of free radicals generated from acyl tellurides has now been shown to form C–C bonds with remarkable fidelity, which enables easy one-step assembly of densely oxygenated natural product motifs.