Reaction mechanisms

Definition

A reaction mechanism is a sequence of elementary reactions that can explain how an overall chemical reaction proceeds.

Latest Research and Reviews

News and Comment

  • News and Views |

    'Click' chemistry allows for the linking together of chemical modules, however, there are currently no methods that also allow for facile 'declicking' to unlink them. Now, a method has been developed to click together amines and thiols, and then allow a chemically triggered declick reaction to release the original molecular components.

    • David A. Fulton
    Nature Chemistry 8, 899–900
  • News and Views |

    Computations of the energetics and mechanism of the Morita–Baylis–Hillman reaction are “not even wrong” when compared with experiments. While computational abstinence may be the purest way to calculate challenging reaction mechanisms, taking prophylactic measures to avoid regrettable outcomes may be more realistic.

    • Arthur Winter
    Nature Chemistry 7, 473–475
  • News and Views |

    The synthesis and isolation of a silane adduct of an electrophilic boron species provides insight into the mechanism of metal-free catalytic reductions based on frustrated Lewis pairs.

    • Douglas W. Stephan
    Nature Chemistry 6, 952–953
  • News and Views |

    High selectivity is essential in the enzymatic biosynthesis of complex natural products. Now, the discovery of multiple sequential bifurcations on the reaction path towards the formation of a diterpenoid shows how dynamics affect selectivity, and suggests how enzymes may steer reactions towards a specific product.

    • Charles E. Hornsby
    •  & Robert S. Paton
    Nature Chemistry 6, 88–89