Raynaud phenomenon

Raynaud phenomenon is an exaggerated physiological response of the extremities to exposure to cold or emotional stress, characterized by ischaemia followed by cyanosis and reperfusion. Primary Raynaud phenomenon is benign, whereas secondary Raynaud phenomenon, which is often associated with underlying connective tissue diseases, can lead to irreversible digital ulceration and gangrene.

Latest Research and Reviews

  • Reviews |

    Systemic sclerosis is an autoimmune disease characterized by vasculopathy-induced fibrosis of the skin and organs that can be life-threatening. Varga and colleagues describe the current views of pathogenesis and treatment, and present an outlook for the future.

    • Yannick Allanore
    • , Robert Simms
    • , Oliver Distler
    • , Maria Trojanowska
    • , Janet Pope
    • , Christopher P. Denton
    •  & John Varga

News and Comment

  • News and Views |

    Early identification of secondary Raynaud phenomenon is essential to treat the underlying disease—most frequently systemic sclerosis (SSc). Integrated therapeutic approaches and monitoring systems that offer improved modalities of care feature in the new best practice recommendations for the treatment of digital vasculopathy in SSc.

    • Maurizio Cutolo
    •  & Alberto Sulli