Raynaud phenomenon is an exaggerated physiological response of the extremities to exposure to cold or emotional stress, characterized by ischaemia followed by cyanosis and reperfusion. Primary Raynaud phenomenon is benign, whereas secondary Raynaud phenomenon, which is often associated with underlying connective tissue diseases, can lead to irreversible digital ulceration and gangrene.
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News and Views |Nature Reviews Rheumatology 11, 569–571