Randomized controlled trials articles from across Nature Portfolio

Randomized controlled trials are clinical trials in which at least two interventions — the test treatment and a control treatment — are simultaneously evaluated in two or more arms of the trial, with enrolment into each arm determined by a random process that ensures freedom from bias. They have been the gold-standard of clinical trials for decades.

Latest Research and Reviews

The Mexican dataset of a repetitive transcranial magnetic stimulation clinical trial on cocaine use disorder patients: SUDMEX TMS
- Diego Angeles-Valdez
- Jalil Rasgado-Toledo
- Eduardo A. Garza-Villarreal
ResearchOpen Access22 Apr 2024 Scientific Data
Volume: 11, P: 408
An Omicron-specific, self-amplifying mRNA booster vaccine for COVID-19: a phase 2/3 randomized trial

A self-amplifying mRNA vaccine shows promise in this new modality by eliciting neutralizing antibodies against the SARS-CoV-2 Omicron (BA.1) variant in a phase 2/3 trial.
- Amit Saraf
- Rohan Gurjar
- Vijaykumar Barge
ResearchOpen Access18 Apr 2024 Nature Medicine
P: 1-10
Role of dietary interventions on microvascular health in South-Asian Surinamese people with type 2 diabetes in the Netherlands: A randomized controlled trial
- Anouk I. M. van der Velden
- Daphne H. T. IJpelaar
- Bernard M. van den Berg
ResearchOpen Access10 Apr 2024 Nutrition & Diabetes
Volume: 14, P: 17
A systematic review and multivariate meta-analysis of the physical and mental health benefits of touch interventions

This pre-registered systematic review and multilevel meta-analysis examined the effects of receiving touch for promoting mental and physical well-being, quantifying the efficacy of touch interventions for different ways of administration.
- Julian Packheiser
- Helena Hartmann
- Frédéric Michon
ResearchOpen Access08 Apr 2024 Nature Human Behaviour
P: 1-20
Effectiveness of low frequency vibration on the rate of canine retraction: a randomized controlled clinical trial
- Mohamed Atfy Abd ElMotaleb
- Amr Ragab El-Beialy
- Ahmed Abdelsalam Eid
ResearchOpen Access04 Apr 2024 Scientific Reports
Volume: 14, P: 7952
Transcranial random noise stimulation (tRNS) improves hot and cold executive functions in children with attention deficit-hyperactivity disorder (ADHD)
- Vahid Nejati
- Mahshid Dehghan
- Michael A. Nitsche
ResearchOpen Access31 Mar 2024 Scientific Reports
Volume: 14, P: 7600

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News and Comment

ALND can be safely omitted for patients with sentinel-node macrometastases
- David Killock
Research Highlights18 Apr 2024 Nature Reviews Clinical Oncology
P: 1
Busulfan plus cyclophosphamide vs. total body irradiation plus cyclophosphamide for allogeneic hematopoietic stem cell transplantation in patients with acute T lymphoblastic leukemia: a large-scale propensity score matching-based study
- Yifan Shen
- Minyuan Liu
- Yang Xu
Correspondence13 Apr 2024 Bone Marrow Transplantation
P: 1-3
FIRSTMAPPP prospectively charts the efficacy of sunitinib for phaeochromocytoma and paraganglioma
- David Killock
Research Highlights08 Mar 2024 Nature Reviews Clinical Oncology
Volume: 21, P: 335
Obesity management strategies should cut fat, not muscle
- Daan Kremer
- Dionne Sizoo
- André P. van Beek
Correspondence04 Mar 2024 International Journal of Obesity
P: 1-2
Adjuvant chemotherapy improves OS in UTUC
- David Killock
Research Highlights22 Feb 2024 Nature Reviews Clinical Oncology
Volume: 21, P: 251
Home exergame prevents falls
- Anna Kriebs
Research Highlights14 Feb 2024 Nature Aging
Volume: 4, P: 167

All News & Comment

Randomized controlled trials articles from across Nature Portfolio

Latest Research and Reviews

The Mexican dataset of a repetitive transcranial magnetic stimulation clinical trial on cocaine use disorder patients: SUDMEX TMS

An Omicron-specific, self-amplifying mRNA booster vaccine for COVID-19: a phase 2/3 randomized trial

Role of dietary interventions on microvascular health in South-Asian Surinamese people with type 2 diabetes in the Netherlands: A randomized controlled trial

A systematic review and multivariate meta-analysis of the physical and mental health benefits of touch interventions

Effectiveness of low frequency vibration on the rate of canine retraction: a randomized controlled clinical trial

Transcranial random noise stimulation (tRNS) improves hot and cold executive functions in children with attention deficit-hyperactivity disorder (ADHD)

News and Comment

ALND can be safely omitted for patients with sentinel-node macrometastases

Busulfan plus cyclophosphamide vs. total body irradiation plus cyclophosphamide for allogeneic hematopoietic stem cell transplantation in patients with acute T lymphoblastic leukemia: a large-scale propensity score matching-based study

FIRSTMAPPP prospectively charts the efficacy of sunitinib for phaeochromocytoma and paraganglioma

Obesity management strategies should cut fat, not muscle

Adjuvant chemotherapy improves OS in UTUC

Home exergame prevents falls

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