Quantitative trait loci

Definition

Quantitative trait loci are regions of the genome at which genetic variation is associated with a particular quantitative trait - for example, height, weight or blood pressure. Quantitative trait loci are identified by showing a statistical association between genetic markers and measurable phenotypes.

Latest Research and Reviews

  • Reviews |

    Disease-resistant crops have the potential to reduce crop losses. This Review discusses how advances in genetic and genomic technologies are contributing to efforts by plant breeders to generate durable, broad-spectrum disease resistance in crop plants.

    • Rebecca Nelson
    • , Tyr Wiesner-Hanks
    • , Randall Wisser
    •  & Peter Balint-Kurti
  • Research | | open

    Hand grip strength as a proxy of muscular fitness is a clinical predictor of mortality and morbidity. In a large-scale GWA study, the authors find 16 robustly associated genetic loci that highlight roles in muscle fibre structure and function, neuronal maintenance and nervous system signal transduction.

    • Sara M. Willems
    • , Daniel J. Wright
    • , Felix R. Day
    • , Katerina Trajanoska
    • , Peter K. Joshi
    • , John A. Morris
    • , Amy M. Matteini
    • , Fleur C. Garton
    • , Niels Grarup
    • , Nikolay Oskolkov
    • , Anbupalam Thalamuthu
    • , Massimo Mangino
    • , Jun Liu
    • , Ayse Demirkan
    • , Monkol Lek
    • , Liwen Xu
    • , Guan Wang
    • , Christopher Oldmeadow
    • , Kyle J. Gaulton
    • , Luca A. Lotta
    • , Eri Miyamoto-Mikami
    • , Manuel A. Rivas
    • , Tom White
    • , Po-Ru Loh
    • , Mette Aadahl
    • , Najaf Amin
    • , John R. Attia
    • , Krista Austin
    • , Beben Benyamin
    • , Søren Brage
    • , Yu-Ching Cheng
    • , Paweł Cięszczyk
    • , Wim Derave
    • , Karl-Fredrik Eriksson
    • , Nir Eynon
    • , Allan Linneberg
    • , Alejandro Lucia
    • , Myosotis Massidda
    • , Braxton D. Mitchell
    • , Motohiko Miyachi
    • , Haruka Murakami
    • , Sandosh Padmanabhan
    • , Ashutosh Pandey
    • , Ioannis Papadimitriou
    • , Deepak K. Rajpal
    • , Craig Sale
    • , Theresia M. Schnurr
    • , Francesco Sessa
    • , Nick Shrine
    • , Martin D. Tobin
    • , Ian Varley
    • , Louise V. Wain
    • , Naomi R. Wray
    • , Cecilia M. Lindgren
    • , Daniel G. MacArthur
    • , Dawn M. Waterworth
    • , Mark I. McCarthy
    • , Oluf Pedersen
    • , Kay-Tee Khaw
    • , Douglas P. Kiel
    • , GEFOS Any-Type of Fracture Consortium
    • , Ling Oei
    • , Hou-Feng Zheng
    • , Vincenzo Forgetta
    • , Aaron Leong
    • , Omar S. Ahmad
    • , Charles Laurin
    • , Lauren E. Mokry
    • , Stephanie Ross
    • , Cathy E. Elks
    • , Jack Bowden
    • , Nicole M. Warrington
    • , Anna Murray
    • , Katherine S. Ruth
    • , Konstantinos K. Tsilidis
    • , Carolina Medina-Gómez
    • , Karol Estrada
    • , Joshua C. Bis
    • , Daniel I. Chasman
    • , Serkalem Demissie
    • , Anke W. Enneman
    • , Yi-Hsiang Hsu
    • , Thorvaldur Ingvarsson
    • , Mika Kähönen
    • , Candace Kammerer
    • , Andrea Z. Lacroix
    • , Guo Li
    • , Ching-Ti Liu
    • , Yongmei Liu
    • , Mattias Lorentzon
    • , Reedik Mägi
    • , Evelin Mihailov
    • , Lili Milani
    • , Alireza Moayyeri
    • , Carrie M. Nielson
    • , Pack Chung Sham
    • , Kristin Siggeirsdotir
    • , Gunnar Sigurdsson
    • , Kari Stefansson
    • , Stella Trompet
    • , Gudmar Thorleifsson
    • , Liesbeth Vandenput
    • , Nathalie van der Velde
    • , Jorma Viikari
    • , Su-Mei Xiao
    • , Jing Hua Zhao
    • , Daniel S. Evans
    • , Steven R. Cummings
    • , Jane Cauley
    • , Emma L. Duncan
    • , Lisette C. P. G. M. de Groot
    • , Tonu Esko
    • , Vilmundar Gudnason
    • , Tamara B. Harris
    • , Rebecca D. Jackson
    • , J Wouter Jukema
    • , Arfan M. A. Ikram
    • , David Karasik
    • , Stephen Kaptoge
    • , Annie Wai Chee Kung
    • , Terho Lehtimäki
    • , Leo-Pekka Lyytikäinen
    • , Paul Lips
    • , Robert Luben
    • , Andres Metspalu
    • , Joyce B. J. van Meurs
    • , Ryan L. Minster
    • , Erick Orwoll
    • , Edwin Oei
    • , Bruce M. Psaty
    • , Olli T. Raitakari
    • , Stuart W. Ralston
    • , Paul M. Ridker
    • , John A. Robbins
    • , Albert V. Smith
    • , Unnur Styrkarsdottir
    • , Gregory J. Tranah
    • , Unnur Thorstensdottir
    • , Andre G. Uitterlinden
    • , Joseph Zmuda
    • , M Carola Zillikens
    • , Evangelia E. Ntzani
    • , Evangelos Evangelou
    • , John P. A. Ioannidis
    • , David M. Evans
    • , Claes Ohlsson
    • , Yannis Pitsiladis
    • , Noriyuki Fuku
    • , Paul W. Franks
    • , Kathryn N. North
    • , Cornelia M. van Duijn
    • , Karen A. Mather
    • , Torben Hansen
    • , Ola Hansson
    • , Tim Spector
    • , Joanne M. Murabito
    • , J. Brent Richards
    • , Fernando Rivadeneira
    • , Claudia Langenberg
    • , John R. B. Perry
    • , Nick J. Wareham
    •  & Robert A. Scott