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Quantitative trait loci are regions of the genome at which genetic variation is associated with a particular quantitative trait - for example, height, weight or blood pressure. Quantitative trait loci are identified by showing a statistical association between genetic markers and measurable phenotypes.
Genomic studies of Heliconius butterflies provide evidence that Heliconius elevatus is a hybrid species, and that its speciation was driven by introgression of traits from Heliconius melpomene into the other parent, an ancestor of Heliconius pardalinus.
Hundreds of arthritis-associated genetic variants have been identified but in most cases their functions remain unknown. Here the authors develop a resource to reveal the effects of variants on gene expression in human synovium, and identify arthritis-related genes.
The Pharma Proteomics Project generates the largest open-access plasma proteomics dataset to date, offering insights into trans protein quantitative trait loci across multiple biological domains, and highlighting genetic influences on ligand–receptor interactions and pathway perturbations across a diverse collection of cytokines and complement networks.
A recent study in Science demonstrates how capturing gene expression over a developmental time course enables the discovery of dynamic expression quantitative trait loci (eQTLs) that would otherwise be challenging to find.
Using a systems genetics approach, a new study identifies genetic variants and proteins associated with plasma and hepatic lipid abundance and hepatic lipotoxicity.
