Psoriatic arthritis

Psoriatic arthritis is a type of seronegative spondyloarthritis characterized by inflammatory arthritis in association with psoriasis. The clinical presentation of psoriatic arthritis is heterogeneous, but often involves the axial joints and distal interphalangeal joints.

Latest Research and Reviews

  • Reviews |

    Dactylitis is diffuse inflammation of the digits and is so closely associated with psoriatic arthritis that it can be used as an outcome measure of it. In this Opinion article, the authors describe how imaging modalities and scoring systems combined with data from animal models can be used to understand the underlying anatomy and immunopathogenesis of dactylitis.

    • Dennis McGonagle
    • , Ai Lyn Tan
    • , Abdulla Watad
    •  & Philip Helliwell
  • Research | | open

    Approximately 30% of psoriasis patients develop psoriatic arthritis (PsA) and early diagnosis is crucial for the management of PsA. Here, Patrick et al. develop a computational pipeline involving statistical and machine-learning methods that can assess the risk of progression to PsA based on genetic markers.

    • Matthew T. Patrick
    • , Philip E. Stuart
    • , Kalpana Raja
    • , Johann E. Gudjonsson
    • , Trilokraj Tejasvi
    • , Jingjing Yang
    • , Vinod Chandran
    • , Sayantan Das
    • , Kristina Callis-Duffin
    • , Eva Ellinghaus
    • , Charlotta Enerbäck
    • , Tõnu Esko
    • , Andre Franke
    • , Hyun M. Kang
    • , Gerald G. Krueger
    • , Henry W. Lim
    • , Proton Rahman
    • , Cheryl F. Rosen
    • , Stephan Weidinger
    • , Michael Weichenthal
    • , Xiaoquan Wen
    • , John J. Voorhees
    • , Gonçalo R. Abecasis
    • , Dafna D. Gladman
    • , Rajan P. Nair
    • , James T. Elder
    •  & Lam C. Tsoi
  • Reviews |

    Evidence from genetic, experimental and clinical studies has accumulated to indicate a role for the IL-17 pathway in the pathogenesis of spondyloarthritis. This Review discusses how IL-17A and IL-17F and their cellular sources contribute to the immunopathology of these diseases.

    • Leonie S. Taams
    • , Kathryn J. A. Steel
    • , Ushani Srenathan
    • , Lachrissa A. Burns
    •  & Bruce W. Kirkham

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