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Protein transport involves the movement of a protein from one cellular or extracellular compartment to another. Protein transport can be facilitated by a variety of pathways including membrane trafficking, protein translocation, and endocytosis or exocytosis.
Lin et al. find that stress-induced p38 MAPK activation leads to cytoplasmic relocation of the Hippo pathway nuclear transcription factor TEAD. TEAD relocation causes inhibition of YAP activity and suppresses YAP-driven cancer cell growth.