Protein transport articles from across Nature Portfolio

How RNA polymerase II subunits enter the nucleus is not well understood. Here, the authors show that Transport and Golgi organization protein 6, TANGO6, recruits RNA polymerase II subunit B2, RPB2, to the ER membrane in a retrograde manner and transports it to the nucleus with the aid of importins.

piRNA processing factors and piRNA/PIWI complex are found in intermitochondrial cement (IMC) and chromatoid body (CB). Here, the authors show that piRNA loading orchestrates MIWI translocation from the IMC to CB, demonstrating its crucial role in spermatogenesis.

Protein function depends on their subcellular location and turnover rate. Here, the authors report a method to measure spatial and temporal proteome dynamics simultaneously, revealing compartment-specific protein turnover and translocation in cardiac cells under ER stress and carfilzomib treatment.

Various carriers are involved in extracellular Wnt transport. Here, the authors show that Wnt heterodimerization with its carrier protein, sFRP2, enhances Wnt accumulation on the cell surface, leading to exosome-mediated Wnt re-secretion.

Soluble ciliary proteins co-opt vesicular transport mechanisms and the exocyst for their transport to the primary cilium. Communications Biology thanks Duarte Barral, Quanlong Lu, and the other, anonymous, reviewer(s) for their contribution to the peer review of this work. Primary Handling Editors: Tiago Dantas and Manuel Breuer. A peer review file is available.

The mitochondrial translocase complex TIM23 targets several hundreds of proteins to their location in the mitochondrial matrix or inner membrane. Recent studies provide important structural and mechanistic insights into the actions of the protein-import machinery in mitochondria.

Antennapedia proteins were among the first proteins found to be exchanged intercellularly. This discovery by Alain Prochiantz and colleagues has inspired researchers of various backgrounds.