Protein sequencing

Protein sequencing refers to methods for determining the amino acid sequence of proteins (or peptides) and analysis of the sequence, for example to infer protein conformation. Techniques include mass spectrometry and the Edman degradation reaction as well as prediction of the protein sequence from the encoding DNA or mRNA sequence.

Latest Research and Reviews

  • Research
    | Open Access

    Exome-sequencing analyses of a large cohort of patients with type 2 diabetes and control individuals without diabetes from five ancestries are used to identify gene-level associations of rare variants that are associated with type 2 diabetes.

    • Jason Flannick
    • , Josep M. Mercader
    • , Christian Fuchsberger
    • , Miriam S. Udler
    • , Anubha Mahajan
    • , Jennifer Wessel
    • , Tanya M. Teslovich
    • , Lizz Caulkins
    • , Ryan Koesterer
    • , Francisco Barajas-Olmos
    • , Thomas W. Blackwell
    • , Eric Boerwinkle
    • , Jennifer A. Brody
    • , Federico Centeno-Cruz
    • , Ling Chen
    • , Siying Chen
    • , Cecilia Contreras-Cubas
    • , Emilio Córdova
    • , Adolfo Correa
    • , Maria Cortes
    • , Ralph A. DeFronzo
    • , Lawrence Dolan
    • , Kimberly L. Drews
    • , Amanda Elliott
    • , James S. Floyd
    • , Stacey Gabriel
    • , Maria Eugenia Garay-Sevilla
    • , Humberto García-Ortiz
    • , Myron Gross
    • , Sohee Han
    • , Nancy L. Heard-Costa
    • , Anne U. Jackson
    • , Marit E. Jørgensen
    • , Hyun Min Kang
    • , Megan Kelsey
    • , Bong-Jo Kim
    • , Heikki A. Koistinen
    • , Johanna Kuusisto
    • , Joseph B. Leader
    • , Allan Linneberg
    • , Ching-Ti Liu
    • , Jianjun Liu
    • , Valeriya Lyssenko
    • , Alisa K. Manning
    • , Anthony Marcketta
    • , Juan Manuel Malacara-Hernandez
    • , Angélica Martínez-Hernández
    • , Karen Matsuo
    • , Elizabeth Mayer-Davis
    • , Elvia Mendoza-Caamal
    • , Karen L. Mohlke
    • , Alanna C. Morrison
    • , Anne Ndungu
    • , Maggie C. Y. Ng
    • , Colm O’Dushlaine
    • , Anthony J. Payne
    • , Catherine Pihoker
    • , Wendy S. Post
    • , Michael Preuss
    • , Bruce M. Psaty
    • , Ramachandran S. Vasan
    • , N. William Rayner
    • , Alexander P. Reiner
    • , Cristina Revilla-Monsalve
    • , Neil R. Robertson
    • , Nicola Santoro
    • , Claudia Schurmann
    • , Wing Yee So
    • , Xavier Soberón
    • , Heather M. Stringham
    • , Tim M. Strom
    • , Claudia H. T. Tam
    • , Farook Thameem
    • , Brian Tomlinson
    • , Jason M. Torres
    • , Russell P. Tracy
    • , Rob M. van Dam
    • , Marijana Vujkovic
    • , Shuai Wang
    • , Ryan P. Welch
    • , Daniel R. Witte
    • , Tien-Yin Wong
    • , Gil Atzmon
    • , Nir Barzilai
    • , John Blangero
    • , Lori L. Bonnycastle
    • , Donald W. Bowden
    • , John C. Chambers
    • , Edmund Chan
    • , Ching-Yu Cheng
    • , Yoon Shin Cho
    • , Francis S. Collins
    • , Paul S. de Vries
    • , Ravindranath Duggirala
    • , Benjamin Glaser
    • , Clicerio Gonzalez
    • , Ma Elena Gonzalez
    • , Leif Groop
    • , Jaspal Singh Kooner
    • , Soo Heon Kwak
    • , Markku Laakso
    • , Donna M. Lehman
    • , Peter Nilsson
    • , Timothy D. Spector
    • , E. Shyong Tai
    • , Tiinamaija Tuomi
    • , Jaakko Tuomilehto
    • , James G. Wilson
    • , Carlos A. Aguilar-Salinas
    • , Erwin Bottinger
    • , Brian Burke
    • , David J. Carey
    • , Juliana C. N. Chan
    • , Josée Dupuis
    • , Philippe Frossard
    • , Susan R. Heckbert
    • , Mi Yeong Hwang
    • , Young Jin Kim
    • , H. Lester Kirchner
    • , Jong-Young Lee
    • , Juyoung Lee
    • , Ruth J. F. Loos
    • , Ronald C. W. Ma
    • , Andrew D. Morris
    • , Christopher J. O’Donnell
    • , Colin N. A. Palmer
    • , James Pankow
    • , Kyong Soo Park
    • , Asif Rasheed
    • , Danish Saleheen
    • , Xueling Sim
    • , Kerrin S. Small
    • , Yik Ying Teo
    • , Christopher Haiman
    • , Craig L. Hanis
    • , Brian E. Henderson
    • , Lorena Orozco
    • , Teresa Tusié-Luna
    • , Frederick E. Dewey
    • , Aris Baras
    • , Christian Gieger
    • , Thomas Meitinger
    • , Konstantin Strauch
    • , Leslie Lange
    • , Niels Grarup
    • , Torben Hansen
    • , Oluf Pedersen
    • , Philip Zeitler
    • , Dana Dabelea
    • , Goncalo Abecasis
    • , Graeme I. Bell
    • , Nancy J. Cox
    • , Mark Seielstad
    • , Rob Sladek
    • , James B. Meigs
    • , Steve S. Rich
    • , Jerome I. Rotter
    • , David Altshuler
    • , Noël P. Burtt
    • , Laura J. Scott
    • , Andrew P. Morris
    • , Jose C. Florez
    • , Mark I. McCarthy
    •  & Michael Boehnke
    Nature 570, 71-76

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