Protein quality control

Protein quality control is the mechanism by which a cell monitors proteins to ensure that they are appropriately folded. Protein quality control takes place predominantly in the endoplasmic reticulum, and can redeliver damaged proteins to the biosynthetic machinery or, failing correction, can deliver them to the ubiquitin–proteasome system for degradation.

Latest Research and Reviews

  • Research |

    Olfactory food perception is known to extend lifespan in C. elegans. Here the authors demonstrate food-odour-dependent brain-to-gut communication that extends lifespan in worms. Food odour downregulates tir-1 mRNA in AWC neurons, in a manner dependent on the miRNA miR-71, which triggers downstream effects in the gut, due to neuropeptide secretion, that promote proteostasis and longevity.

    • Fabian Finger
    • , Franziska Ottens
    • , Alexander Springhorn
    • , Tanja Drexel
    • , Lucie Proksch
    • , Sophia Metz
    • , Luisa Cochella
    •  & Thorsten Hoppe
  • Research | | open

    Makiko Kawaguchi et al. developed an inducible Spint2 knockout mouse model which exhibited extensive damage to the intestinal epithelium and resulted in death six days after tamoxifen-induced gene ablation. The extreme phenotype observed in this inducible line suggests an important role for Spint2 in maintenance of healthy intestinal epithelium.

    • Makiko Kawaguchi
    • , Koji Yamamoto
    • , Naoki Takeda
    • , Tsuyoshi Fukushima
    • , Fumiki Yamashita
    • , Katsuaki Sato
    • , Kenichiro Kitamura
    • , Yoshitaka Hippo
    • , James W. Janetka
    •  & Hiroaki Kataoka
  • Research | | open

    Ischemic reperfusion or nutrient deprivation that produces reactive oxygen species can lead to a loss of muscle contractile function. Here the authors show that glutathionylation of the lysine methyltransferase SMYD2 contributes to degradation or disassembly of sarcomeres.

    • Dhanushka N. P. Munkanatta Godage
    • , Garrett C. VanHecke
    • , Kusal T. G. Samarasinghe
    • , Han-Zhong Feng
    • , Mark Hiske
    • , Joshua Holcomb
    • , Zhe Yang
    • , Jian-Ping Jin
    • , Charles S. Chung
    •  & Young-Hoon Ahn
  • Reviews |

    Cellular stress responses primarily serve to rectify stress-associated damage. However, these responses are also coupled with the generation of various signals that are transmitted to the cellular microenvironments or even across tissues. This communication generally supports the maintenance of systemic homeostasis but can also result in pathology.

    • Lorenzo Galluzzi
    • , Takahiro Yamazaki
    •  & Guido Kroemer

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