Population genetics

Population genetics is the study of the genetic composition of populations, including distributions and changes in genotype and phenotype frequency in response to the processes of natural selection, genetic drift, mutation and gene flow.

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Latest Research and Reviews

  • Research | | open

    Estimates of the burden of malaria often don't take wider, indirect effects on overall health into consideration. Here, Uyoga et al. estimate the indirect impact of malaria on children’s health in a case-control study, using the sickle cell trait as a proxy indicator for an effective intervention.

    • Sophie Uyoga
    • , Alex W. Macharia
    • , Carolyne M. Ndila
    • , Gideon Nyutu
    • , Mohammed Shebe
    • , Kennedy O. Awuondo
    • , Neema Mturi
    • , Norbert Peshu
    • , Benjamin Tsofa
    • , J. Anthony G. Scott
    • , Kathryn Maitland
    •  & Thomas N. Williams
    Nature Communications 10, 856

  • Research | | open

    The burden of asthma varies between ancestries, but GWAS have so far focused on mainly European ancestry populations. Here, Daya et al. perform GWAS for asthma in 14,654 individuals of African ancestry and, besides confirming previously known loci, identify two potentially African ancestry-specific loci.

    • Michelle Daya
    • , Nicholas Rafaels
    • , Tonya M. Brunetti
    • , Sameer Chavan
    • , Albert M. Levin
    • , Aniket Shetty
    • , Christopher R. Gignoux
    • , Meher Preethi Boorgula
    • , Genevieve Wojcik
    • , Monica Campbell
    • , Candelaria Vergara
    • , Dara G. Torgerson
    • , Victor E. Ortega
    • , Ayo Doumatey
    • , Henry Richard Johnston
    • , Nathalie Acevedo
    • , Maria Ilma Araujo
    • , Pedro C. Avila
    • , Gillian Belbin
    • , Eugene Bleecker
    • , Carlos Bustamante
    • , Luis Caraballo
    • , Alvaro Cruz
    • , Georgia M. Dunston
    • , Celeste Eng
    • , Mezbah U. Faruque
    • , Trevor S. Ferguson
    • , Camila Figueiredo
    • , Jean G. Ford
    • , Weiniu Gan
    • , Pierre-Antoine Gourraud
    • , Nadia N. Hansel
    • , Ryan D. Hernandez
    • , Edwin Francisco Herrera-Paz
    • , Silvia Jiménez
    • , Eimear E. Kenny
    • , Jennifer Knight-Madden
    • , Rajesh Kumar
    • , Leslie A. Lange
    • , Ethan M. Lange
    • , Antoine Lizee
    • , Pissamai Maul
    • , Trevor Maul
    • , Alvaro Mayorga
    • , Deborah Meyers
    • , Dan L. Nicolae
    • , Timothy D. O’Connor
    • , Ricardo Riccio Oliveira
    • , Christopher O. Olopade
    • , Olufunmilayo Olopade
    • , Zhaohui S. Qin
    • , Charles Rotimi
    • , Nicolas Vince
    • , Harold Watson
    • , Rainford J. Wilks
    • , James G. Wilson
    • , Steven Salzberg
    • , Carole Ober
    • , Esteban G. Burchard
    • , L. Keoki Williams
    • , Terri H. Beaty
    • , Margaret A. Taub
    • , Ingo Ruczinski
    • , Rasika A. Mathias
    • , Kathleen C. Barnes
    • , Ayola Akim Adegnika
    • , Ganiyu Arinola
    • , Ulysse Ateba-Ngoa
    • , Gerardo Ayestas
    • , Hilda Bjarnadóttir
    • , Adolfo Correa
    • , Said Omar Leiva Erazo
    • , Marilyn G. Foreman
    • , Cassandra Foster
    • , Li Gao
    • , Jingjing Gao
    • , Leslie Grammer
    • , Mark Hansen
    • , Tina Hartert
    • , Yijuan Hu
    • , Iain Königsberg
    • , Kwang-Youn A. Kim
    • , Pamela Landaverde-Torres
    • , Javier Marrugo
    • , Beatriz Martinez
    • , Rosella Martinez
    • , Luis F. Mayorga
    • , Delmy-Aracely Mejia-Mejia
    • , Catherine Meza
    • , Solomon Musani
    • , Shaila Musharoff
    • , Oluwafemi Oluwole
    • , Maria Pino-Yanes
    • , Hector Ramos
    • , Allan Saenz
    • , Maureen Samms-Vaughan
    • , Robert Schleimer
    • , Alan F. Scott
    • , Suyash S. Shringarpure
    • , Wei Song
    • , Zachary A. Szpiech
    • , Raul Torres
    • , Gloria Varela
    • , Olga Marina Vasquez
    • , Francisco M. De La Vega
    • , Lorraine B. Ware
    •  & Maria Yazdanbakhsh
    Nature Communications 10, 880

  • Research | | open

    Negative selection removes deleterious genetic variation, and can influence genetic architectures and evolution of complex traits. Here, the authors analyze data from 25 UK Biobank diseases and complex traits, and quantify frequency-dependent genetic architectures which suggests actions of negative selection.

    • Armin P. Schoech
    • , Daniel M. Jordan
    • , Po-Ru Loh
    • , Steven Gazal
    • , Luke J. O’Connor
    • , Daniel J. Balick
    • , Pier F. Palamara
    • , Hilary K. Finucane
    • , Shamil R. Sunyaev
    •  & Alkes L. Price
    Nature Communications 10, 790

  • Research | | open

    • Elena A. Vidal
    • , Tomás C. Moyano
    • , Bernabé I. Bustos
    • , Eduardo Pérez-Palma
    • , Carol Moraga
    • , Eleodoro Riveras
    • , Alejandro Montecinos
    • , Lorena Azócar
    • , Daniela C. Soto
    • , Mabel Vidal
    • , Alex Di Genova
    • , Klaus Puschel
    • , Peter Nürnberg
    • , Stephan Buch
    • , Jochen Hampe
    • , Miguel L. Allende
    • , Verónica Cambiazo
    • , Mauricio González
    • , Christian Hodar
    • , Martín Montecino
    • , Claudia Muñoz-Espinoza
    • , Ariel Orellana
    • , Angélica Reyes-Jara
    • , Dante Travisany
    • , Paula Vizoso
    • , Mauricio Moraga
    • , Susana Eyheramendy
    • , Alejandro Maass
    • , Giancarlo V. De Ferrari
    • , Juan Francisco Miquel
    •  & Rodrigo A. Gutiérrez
    Scientific Reports 9, 2132
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