PolyADP-ribosylation, also known as parylation, is the post-translational modification process by which polymers of ADP-ribose (poly(adenosinediphosphate-ribose)) are covalently attached to proteins by PAR polymerase enzymes. The polymerase covalently attaches poly(ADP-ribose) polymer to itself and appropriate acceptors such as histones and other DNA-associated proteins. Parylation regulates chromatin organization, DNA repair, transcription and replication and other processes.
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News and Views |Nature Structural and Molecular Biology 20, 407–408