Pituitary tumours

Pituitary tumours are cancers of the pituitary gland. Pituitary tumours can be classified as functioning (able to produce hormones) or non-functioning.

Latest Research and Reviews

  • Research | | open

    LncRNA H19 has been shown to be aberrantly expressed in different cancers. Here, the authors show that H19 lncRNA is downregulated in pituitary adenomas and H19 is able to impede pituitary tumorigenesis via disruption of 4E-BPB1 and Raptor interaction to inhibit the phosphorylation of 4E-BP1.

    • Ze Rui Wu
    • , Lichong Yan
    • , Yan Ting Liu
    • , Lei Cao
    • , Yu Hang Guo
    • , Yong Zhang
    • , Hong Yao
    • , Lin Cai
    • , Han Bing Shang
    • , Wei Wei Rui
    • , Gang Yang
    • , Xiao Biao Zhang
    • , Hao Tang
    • , Yu Wang
    • , Jin Yan Huang
    • , Yong Xu Wei
    • , Wei Guo Zhao
    • , Bing Su
    •  & Zhe Bao Wu
  • Reviews |

    Pituitary gigantism is a rare growth disorder caused by excessive release of growth hormone and insulin-like growth factor 1. This Review discusses the diagnosis, genetic causes and clinical management of pituitary gigantism.

    • Albert Beckers
    • , Patrick Petrossians
    • , Julien Hanson
    •  & Adrian F. Daly
  • Research | | open

    In this study the authors report USP48 and BRAF are frequently mutated in USP8 wild-type corticotroph adenomas, and cause Cushing’s disease mainly through promoting the promoter activity of POMC. Inhibition of BRAF may be a promising therapeutic strategy for the treatment of patients with BRAF-mutated corticotroph adenomas.

    • Jianhua Chen
    • , Xuemin Jian
    • , Siyu Deng
    • , Zengyi Ma
    • , Xuefei Shou
    • , Yue Shen
    • , Qilin Zhang
    • , Zhijian Song
    • , Zhiqiang Li
    • , Hong Peng
    • , Cheng Peng
    • , Min Chen
    • , Cheng Luo
    • , Dan Zhao
    • , Zhao Ye
    • , Ming Shen
    • , Yichao Zhang
    • , Juan Zhou
    • , Aamir Fahira
    • , Yongfei Wang
    • , Shiqi Li
    • , Zhaoyun Zhang
    • , Hongying Ye
    • , Yiming Li
    • , Jiawei Shen
    • , Hong Chen
    • , Feng Tang
    • , Zhenwei Yao
    • , Zhifeng Shi
    • , Chunjui Chen
    • , Lu Xie
    • , Ye Wang
    • , Chaowei Fu
    • , Ying Mao
    • , Liangfu Zhou
    • , Daming Gao
    • , Hai Yan
    • , Yao Zhao
    • , Chuanxin Huang
    •  & Yongyong Shi
  • Reviews | | open

    Acromegaly is usually caused by a pituitary adenoma that secretes growth hormone; treatment of acromegaly and its comorbidities is often complex. In this Consensus Statement, Shlomo Melmed and colleagues provide updated recommendations for the treatment of patients with acromegaly.

    • Shlomo Melmed
    • , Marcello D. Bronstein
    • , Philippe Chanson
    • , Anne Klibanski
    • , Felipe F. Casanueva
    • , John A. H. Wass
    • , Christian J. Strasburger
    • , Anton Luger
    • , David R. Clemmons
    •  & Andrea Giustina

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