Physiology

Definition

Physiology is the branch of the biological sciences that deals with the life-supporting functions and processes of living organisms or their parts. The study of physiology aims to understand how living things work, which can then aid the treatment of diseases.

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Latest Research and Reviews

  • Reviews |

    Chronic kidney disease (CKD) is the progressive, irreversible loss of renal function that has many causes and contributing factors. In this Primer, the authors describe the many consequences of CKD and how understanding — and treating — the underlying cause can substantially slow CKD progression.

    • Paola Romagnani
    • , Giuseppe Remuzzi
    • , Richard Glassock
    • , Adeera Levin
    • , Kitty J. Jager
    • , Marcello Tonelli
    • , Ziad Massy
    • , Christoph Wanner
    •  & Hans-Joachim Anders
  • Research |

    A pathway for the production of aromatic amino acid metabolites in Clostridium sporogenes is described; modulation of serum levels of these metabolites in gnotobiotic mice affects intestinal permeability and systemic immunity.

    • Dylan Dodd
    • , Matthew H. Spitzer
    • , William Van Treuren
    • , Bryan D. Merrill
    • , Andrew J. Hryckowian
    • , Steven K. Higginbottom
    • , Anthony Le
    • , Tina M. Cowan
    • , Garry P. Nolan
    • , Michael A. Fischbach
    •  & Justin L. Sonnenburg
  • Research |

    Cancers growing in high-oxygen environments, such as lung adenocarcinomas, select for the iron–sulfur cluster synthesizing enzyme NFS1 to support malignant proliferation and to protect from oxidative damage.

    • Samantha W. Alvarez
    • , Vladislav O. Sviderskiy
    • , Erdem M. Terzi
    • , Thales Papagiannakopoulos
    • , Andre L. Moreira
    • , Sylvia Adams
    • , David M. Sabatini
    • , Kıvanç Birsoy
    •  & Richard Possemato
  • Reviews |

    Cells activate a transcriptional response known as the mitochondrial unfolded protein response (UPRmt) when mitochondrial integrity and function are impaired to promote their recovery. Recent insights into the regulation, mechanisms and functions of the UPRmt have uncovered important links to ageing and ageing-associated diseases.

    • Tomer Shpilka
    •  & Cole M. Haynes
  • Research | | open

    KCNQ1 is a voltage-gated potassium channel that is important in cardiac and epithelial function. Here the authors present a mechanism for KCNQ1 activation and inactivation in which voltage sensor activation promotes pore opening more effectively in the intermediate open state than the fully open state, generating inactivation.

    • Panpan Hou
    • , Jodene Eldstrom
    • , Jingyi Shi
    • , Ling Zhong
    • , Kelli McFarland
    • , Yuan Gao
    • , David Fedida
    •  & Jianmin Cui

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