Phosphoinositol signalling articles from across Nature Portfolio

INPP5E is shown to be involved in the process of proximal TCR signaling activation at the immune synapse by providing a preferable phosphoinositide microenvironment via hydrolyzing PI(4,5)P2 at the plasma membrane, regulating complex formation with CD3ζ, ZAP-70, and Lck, allowing proximal TCR signaling and T cell activation.

Tan and Finkel report a novel phosphoinositide-initiated membrane tethering and lipid transport (PITT) pathway that is crucial for lysosome membrane repair.

Protein kinases are key regulators of excitatory synapse plasticity. In this issue, using novel optical reporters of protein kinase C (PKC) activity, Colgan et al. identify PKCα as critical for integrating NMDA receptor and neurotrophin signaling to control dendritic spine structural plasticity, synaptic potentiation, and learning and memory.

The specific binding of the lincRNALINK-A tothe phospholipid PIP₃and the kinase AKT activates AKT and promotes tumorigenesis and resistance to AKT inhibitors.