Phosphoinositol signalling

Definition

Phosphoinositol signalling is a cell signalling pathway. Extracellular signals promote activation of phospholipase C, which cleaves the phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) into inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 and DAG go on to increase intracellular calcium levels and activate protein kinase C.

Latest Research and Reviews

News and Comment