A pheromone is a chemical substance that is secreted or excreted by an organism into the environment, which evokes physiological and/or social responses in one or more organisms of the same species. Perception of these chemical signals may be by olfaction or by contact.

Latest Research and Reviews

  • Research | | open

    Olfactory experience can alter the relative abundance of neurons expressing specific chemoreceptors. Here, the authors demonstrate that the distinct odor experiences of sex-separated male and female mice induce sex-specific differences in the abundance of neurons that detect sexually dimorphic odors.

    • Carl van der Linden
    • , Susanne Jakob
    • , Pooja Gupta
    • , Catherine Dulac
    •  & Stephen W. Santoro
  • Research | | open

    Sex pheromones that increase mating have been reported across a number of different species, yet there is little known about pheromones that suppress female mating drive. This study reports that juvenile female mice release a pheromone, ESP22, which suppresses sexual receptivity of adult female mice by evoking a robust rejection behavior upon male mounting.

    • Takuya Osakada
    • , Kentaro K. Ishii
    • , Hiromi Mori
    • , Ryo Eguchi
    • , David M. Ferrero
    • , Yoshihiro Yoshihara
    • , Stephen D. Liberles
    • , Kazunari Miyamichi
    •  & Kazushige Touhara
  • Research | | open

    Mate preference and copulatory behavior in female rodents are coordinated with the ovulation cycles of the animal. This study shows that hypothalamic kisspeptin neurons control both mate choice and copulation, and therefore, that sexual behavior and ovulation may be synchronized by the same neuropeptide.

    • Vincent Hellier
    • , Olivier Brock
    • , Michael Candlish
    • , Elodie Desroziers
    • , Mari Aoki
    • , Christian Mayer
    • , Richard Piet
    • , Allan Herbison
    • , William Henry Colledge
    • , Vincent Prévot
    • , Ulrich Boehm
    •  & Julie Bakker
  • Research |

    Social behaviors require neural circuits to process social cues and orchestrate motivational states. This study identifies a subpopulation of hypothalamic neurons expressing neurotensin that are engaged by social and hormonal signals. These neurons project to midbrain dopaminergic reward systems to promote and reinforce social and motivated behavior in a hormone-sensitive manner.

    • Jenna A McHenry
    • , James M Otis
    • , Mark A Rossi
    • , J Elliott Robinson
    • , Oksana Kosyk
    • , Noah W Miller
    • , Zoe A McElligott
    • , Evgeny A Budygin
    • , David R Rubinow
    •  & Garret D Stuber
    Nature Neuroscience 20, 449-458
  • Research | | open

    Male pheromones cis-vaccenyl acetate (cVA) and (Z)-7-Tricosene (7-T) mediate chemical mate-guarding in female D. melanogaster. Here, Laturney and Billeter show that females actively eject cVA from their reproductive tract post-copulation, and that cVA in concert with 7-T can reduce female attractiveness post-mating.

    • Meghan Laturney
    •  & Jean-Christophe Billeter

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