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Pharmacodynamics (PD) is an area of pharmacology concerned with the relationship between a drug’s concentration at the site of action and the resulting effect, and to measurement of that relationship within an individual or group. Factors influencing a drug’s pharmacodynamics include the concentration of drug target and the signalling pathways downstream.
Use of a cAMP biosensor to study real-time mechano-sensitive enhancement of β2-adrenoceptor constitutive activity and its inhibition by β2-inverse agonists in HEK 293 cells.
