Peripheral tolerance

Peripheral tolerance describes the mechanisms that take place outside of primary lymphoid tissues to prevent lymphocytes from initiating potentially dangerous immune responses against the body’s own tissues, or against other harmless materials, such as food or commensal organisms.

Latest Research and Reviews

News and Comment

  • News and Views |

    The mechanism of action of the lymphocyte checkpoint protein LAG-3 was always rather mysterious. It now seems to operate at least in part by recognizing and suppressing responses to stable complexes of peptide and major histocompatibility complex class II.

    • Yuan Lui
    •  & Simon J. Davis
    Nature Immunology 19, 1278-1279
  • News and Views |

    The accumulation of intestinal Foxp3+ regulatory T cells (Treg cells) in response to the microbiota is tightly regulated. Epithelial apoptosis inhibits the production of tolerogenic interferon-β by myeloid cells and thereby reduces the frequency of Treg cells and lowers the threshold for inflammatory responses.

    • Johanna Pott
    • , Kevin J Maloy
    •  & Ana Izcue
    Nature Immunology 17, 349-350
  • News and Views |

    Thymic selection shapes the repertoire of potentially autoreactive thymocytes that are allowed to mature. The expression pattern of self antigen seen by thymocytes determines the number and functional ability of autoreactive T cells.

    • Douglas G Millar
    •  & Pamela S Ohashi
    Nature Immunology 17, 115-116