Peptides are amino acid polymers. They are generally much smaller than proteins and don’t have sufficient activity on their own – they generally represent a small portion of a full protein. They may also be signalling molecules that act through interaction with specific receptors, as in peptide hormones and cytokines.

Latest Research and Reviews

News and Comment

  • News and Views |

    Bacterial communication is a potential strategy to control bacterial behaviours and thus, attenuate pathogen infectivity; however, identifying the signalling molecules that regulate communication pathways is challenging. Now, a robust strategy to rapidly identify previously unknown signalling peptides has been developed. This approach provides a means to map out and decipher bacterial signalling mechanisms.

    • Dominic N. McBrayer
    •  & Yftah Tal-Gan
    Nature Chemistry 11, 398-399
  • News and Views |

    Powerful combinatorial peptide library methods allow the discovery of peptide leads from diverse libraries. A new platform based on tandem mass spectrometry peptide sequencing coupled with high-performance size-exclusion chromatography enables identification of high-affinity peptidic ligands from focused libraries.

    • Kit S. Lam
  • News and Views |

    T cell cross-reactivity enables the immune system to recognize a large array of peptides. A new study shows that T cells can achieve cross-recognition by using the remarkable plasticity of peptides, through flipping the peptide out of the binding cleft.

    • Stephanie Gras
  • Editorial |

    Encoded chemical libraries can be used to screen a vast array of compounds against a protein target to identify potent binders. A collection of articles in this issue discuss different methods to increase the chemical space sampled by encoded macrocycle libraries and the advantages that such libraries offer for discovering new drug leads.