Peptide hormones articles from across Nature Portfolio

Amino acids modulate insulin secretion via amino acid transporters expressed on β cells. Here, the authors show a VGF-derived peptide NERP-4 acts as a positive allosteric modulator on the amino acid transporter SNAT2/SLC38A2, thereby contributing to β-cell maintenance and function.

Comparison of binding and activation abilities for all three Insulin-like Growth Factor-2 unglycosylated proforms shows that proforms proIGF2(156) and big-IGF2(104) may be disease-associated accumulating hormones.

In this work, the authors highlight that conserved receptor binding segments of class B GPCR ligands have a dual nature: they serve as amyloid-prone regions involved in pH-dependent conversion from secretory amyloid fibrils to the functional folded form.