Peptide hormones

Peptide hormones are hormones that consist of amino acids. Peptide hormones can be among the intracellular signalling peptides and proteins, and can include insect hormones, gastrointestinal hormones and thyroid hormones, but their actions are not limited to individual cells and they can act systemically.

Latest Research and Reviews

  • Reviews |

    Acromegaly is a hormonal disorder that is usually caused by a growth hormone-secreting pituitary tumour. This Primer by Colao and colleagues reviews the pathogenesis, diagnosis and management of acromegaly and discusses the quality of life of patients and future outlooks.

    • Annamaria Colao
    • , Ludovica F. S. Grasso
    • , Andrea Giustina
    • , Shlomo Melmed
    • , Philippe Chanson
    • , Alberto M. Pereira
    •  & Rosario Pivonello
  • Research | | open

    The structures of amyloid fibres are currently primarily studied through solid state NMR and cryo-EM. Here the authors present a free-standing graphene support device that allows diffraction imaging of non-crystalline amyloid fibrils with single X-ray pulses from an X-ray free-electron laser.

    • Carolin Seuring
    • , Kartik Ayyer
    • , Eleftheria Filippaki
    • , Miriam Barthelmess
    • , Jean-Nicolas Longchamp
    • , Philippe Ringler
    • , Tommaso Pardini
    • , David H. Wojtas
    • , Matthew A. Coleman
    • , Katerina Dörner
    • , Silje Fuglerud
    • , Greger Hammarin
    • , Birgit Habenstein
    • , Annette E. Langkilde
    • , Antoine Loquet
    • , Alke Meents
    • , Roland Riek
    • , Henning Stahlberg
    • , Sébastien Boutet
    • , Mark S. Hunter
    • , Jason Koglin
    • , Mengning Liang
    • , Helen M. Ginn
    • , Rick P. Millane
    • , Matthias Frank
    • , Anton Barty
    •  & Henry N. Chapman
  • Research | | open

    The synthesis and folding pathways of insulin and related proteins are of wide interest. Here the authors characterise the major two-chain oxidative folding pathways of bovine pancreatic insulin, and develop synthetic conditions applicable to related foldable insulin variants

    • Kenta Arai
    • , Toshiki Takei
    • , Reina Shinozaki
    • , Masato Noguchi
    • , Shouta Fujisawa
    • , Hidekazu Katayama
    • , Luis Moroder
    • , Setsuko Ando
    • , Masaki Okumura
    • , Kenji Inaba
    • , Hironobu Hojo
    •  & Michio Iwaoka
  • Reviews |

    In this Review, the authors chart the history of growth hormone, from discovery to clinical development and therapeutic approval, and discuss the emerging pathophysiology and treatment of its related growth disorders, particularly in childhood. Finally, more recent developments and future strategies are highlighted.

    • Michael B. Ranke
    •  & Jan M. Wit

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