Peptide delivery

Peptide delivery is a method by which peptides are delivered into cells. Peptides could be used as drugs, for example to treat bacterial infections. Nanoparticles — particles of 1-100nm in size — and specially designed polymers have been used to deliver peptides into cells.

Latest Research and Reviews

News and Comment

  • News and Views |

    An amphipathic peptide has been engineered and is capable of penetrating the blood–brain barrier as well as possessing a potent antiviral activity against Zika and other mosquito-borne viruses.

    • Jing Zou
    •  & Pei-Yong Shi
    Nature Materials 17, 955-956
  • News and Views |

    A study demonstrates that controlled integrin binding on a biomaterial was capable of promoting vascular cell sprouting and formation of a non-leaky blood vessel network in a healthy and diseased state.

    • Michael R. Blatchley
    •  & Sharon Gerecht
    Nature Materials 16, 881-883
  • News and Views |

    Intracellular protein delivery has been a major challenge in the field of cell biology for decades. Engineering such delivery is a key step in the development of protein- and antibody-based therapeutics. Now, two different approaches that enable the delivery of antibodies and antibody fragments into the cytosol have been developed.

    • Macarena Sánchez-Navarro
    • , Meritxell Teixidó
    •  & Ernest Giralt
    Nature Chemistry 9, 727-728
  • News and Views |

    Conjugation of a diabetes drug with a brush polymer reduces the reactivity of the drug conjugate towards pre-existing polymer antibodies in human plasma and improves the drug's performance in diabetic mice.

    • Kang Choon Lee
    •  & Seulki Lee