Parathyroid hormone

Parathyroid hormone is a hormone synthesized and released into the blood stream by the parathyroid glands. It regulates phosphorous and calcium metabolism in the body and functions in neuromuscular excitation and blood clotting.

Latest Research and Reviews

  • Research | | open

    Parathyroid hormone (PTH) is used to treat osteoporosis, but its therapeutic mechanism remains unclear. Here, the authors show that Tgif1 is a PTH target gene, and that its deletion impairs the function of osteoblasts and PTH-induced bone formation in mice.

    • Hiroaki Saito
    • , Andreas Gasser
    • , Simona Bolamperti
    • , Miki Maeda
    • , Levi Matthies
    • , Katharina Jähn
    • , Courtney L. Long
    • , Hartmut Schlüter
    • , Marcel Kwiatkowski
    • , Vaibhav Saini
    • , Paola Divieti Pajevic
    • , Teresita Bellido
    • , Andre J. van Wijnen
    • , Khalid S. Mohammad
    • , Theresa A. Guise
    • , Hanna Taipaleenmäki
    •  & Eric Hesse
  • Reviews |

    Hypoparathyroidism is a disease characterized by inadequately low circulating levels of parathyroid hormone resulting in low calcium levels and increased phosphate levels in the blood. In this Primer, Mannstadt et al. summarize current knowledge of the prevalence, pathophysiology, clinical presentation and management of hypoparathyroidism.

    • Michael Mannstadt
    • , John P. Bilezikian
    • , Rajesh V. Thakker
    • , Fadil M. Hannan
    • , Bart L. Clarke
    • , Lars Rejnmark
    • , Deborah M. Mitchell
    • , Tamara J. Vokes
    • , Karen K. Winer
    •  & Dolores M. Shoback
  • Reviews |

    Primary hyperparathyroidism (PHPT) is characterized by excessive secretion of parathyroid hormone due to a single benign adenoma or multiglandular disease. In this Primer, Bilezikian et al. describe the epidemiology, clinical presentations, genetics, evaluation and guidelines for the management of PHPT.

    • John P. Bilezikian
    • , Natalie E. Cusano
    • , Aliya A. Khan
    • , Jian-Min Liu
    • , Claudio Marcocci
    •  & Francisco Bandeira
  • Reviews |

    The calcium-sensing receptor (CaSR) can detect small changes in serum calcium levels and feeds back to modulate parathyroid hormone secretion to elicit appropriate biological responses in different tissues. In this Review, Daniela Riccardi and Giovanna Valenti describe the localization of the CaSR within the nephron and outline its differential functions in different nephron segments. They outline how modulation of the CaSR by pharmacologic approaches could be used in the therapeutic management of disorders such as hyperparathyroidism or hypercalciuric disorders.

    • Daniela Riccardi
    •  & Giovanna Valenti

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