Parathyroid hormone articles from across Nature Portfolio

Osteoarthritis is a common disease that causes pain and difficulty moving joints. Here the authors present an injectable gelatin-based hydrogel that slowly releases teriparatide drug to avoid frequent injections, offering a potential solution for patients with osteoarthritis.

This Review considers the principal regulators of the processes of biomineralization and crystallization in human physiology. In addition, disorders of biomineralization are discussed, including bone disorders and disorders of extraskeletal mineralization.

Parathyroid hormone (PTH) is used to treat osteoporosis, but its therapeutic mechanism remains unclear. Here, the authors show that Tgif1 is a PTH target gene, and that its deletion impairs the function of osteoblasts and PTH-induced bone formation in mice.

Hypoparathyroidism is characterized by hypocalcaemia and inadequately low circulating levels of parathyroid hormone. This PrimeView focuses on the different causes of this rare condition, which include damage or inadvertent removal of the parathyroid gland during neck surgery and genetic, idiopathic and autoimmune aetiologies.