Paediatric rheumatic diseases

Definition

Paediatric rheumatic diseases is an umbrella term that encompasses the spectrum of musculoskeletal, arthritic and connective tissue disorders with onset in childhood.

Latest Research and Reviews

  • Reviews |

    A growing body of evidence supports a shift away from bed rest and inactivity to prescribing physical activity for children and adolescents with rheumatic diseases. Increasing physical activity levels, as well as reducing hypoactivity, can improve symptoms and outcomes in this paediatric population.

    • Bruno Gualano
    • , Eloisa Bonfa
    • , Rosa M. R. Pereira
    •  & Clovis A. Silva
  • Research | | open

    DEK is a secreted protein abundant in the synovia of patients with juvenile idiopathic arthritis. Here the authors show DEK is important for neutrophil extracellular trap formation and joint inflammation, and demonstrate therapeutic efficacy of DEK-targeting aptamers in a mouse model of arthritis.

    • Nirit Mor-Vaknin
    • , Anjan Saha
    • , Maureen Legendre
    • , Carmelo Carmona-Rivera
    • , M Asif Amin
    • , Bradley J. Rabquer
    • , Marta J. Gonzales-Hernandez
    • , Julie Jorns
    • , Smriti Mohan
    • , Srilakshmi Yalavarthi
    • , Dave A. Pai
    • , Kristine Angevine
    • , Shelley J. Almburg
    • , Jason S. Knight
    • , Barbara S. Adams
    • , Alisa E. Koch
    • , David A. Fox
    • , David R. Engelke
    • , Mariana J. Kaplan
    •  & David M. Markovitz
  • Reviews |

    Macrophage activation syndrome (MAS) is a potentially fatal complication of rheumatic disease, most notably systemic juvenile idiopathic arthritis. Findings from studies in animal models and from clinical observations, particularly in relation to the effects of anticytokine biologic therapies, have led to new concepts of the pathophysiology of this phenomenon.

    • Alexei A. Grom
    • , AnnaCarin Horne
    •  & Fabrizio De Benedetti
  • Reviews |

    The most common form of eye inflammation associated with juvenile idiopathic arthritis (JIA) is chronic anterior uveitis, which, if inadequately treated, can lead to ocular complications, including blindness. Sen and colleagues discuss the epidemiology, immunopathogenesis and management of JIA-associated uveitis, and describe the potential for biomarkers to improve its treatment.

    • Ethan S. Sen
    • , Andrew D. Dick
    •  & Athimalaipet V. Ramanan
  • Reviews |

    Promising biomarkers are being developed to predict disease outcome and response to therapy in children with juvenile idiopathic arthritis, childhood lupus nephritis and juvenile idiopathic inflammatory myopathies. These advances are expected to facilitate risk stratification, diagnosis and management of these patients, and thereby lead to more rational and effective clinical care.

    • Alessandro Consolaro
    • , Giulia C. Varnier
    • , Alberto Martini
    •  & Angelo Ravelli

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