Osteopontin

Osteopontin is an acidic phosphoprotein produced by osteoblasts and other cell types. Osteopontin is an extracellular protein that has a cell-adhesion sequence (RGD) that mediates its interaction with integrins and extracellular matrix components. It has functions in biomineralization of bone, chemotaxis, apoptosis and cell activation in immunity.

Latest Research and Reviews

Research | 29 December 2016 | open

Osteopontin facilitates tumor metastasis by regulating epithelial–mesenchymal plasticity
- Rongjie Jia
- , Yingchao Liang
- , Rui Chen
- , Guoke Liu
- , Hao Wang
- , Min Tang
- , Xuyu Zhou
- , Huajing Wang
- , Yang Yang
- , Huafeng Wei
- , Bohua Li
- , Yipeng Song
- & Jian Zhao
Cell Death & Disease 7, e2564
Research | 25 August 2016

Plasma thrombin-cleaved osteopontin as a potential biomarker of acute atherothrombotic ischemic stroke
- Saya Ozaki
- , Mie Kurata
- , Yoshiaki Kumon
- , Shirabe Matsumoto
- , Masahiko Tagawa
- , Hideaki Watanabe
- , Shiro Ohue
- , Jitsuo Higaki
- & Takanori Ohnishi
Hypertension Research 40, 61-66
Research | 21 April 2016 | open

Metastasis-inducing proteins are widely expressed in human brain metastases and associated with intracranial progression and radiation response
- Rasheed Zakaria
- , Angela Platt-Higgins
- , Nitika Rathi
- , Daniel Crooks
- , Andrew Brodbelt
- , Emmanuel Chavredakis
- , David Lawson
- , Michael D Jenkinson
- & Philip S Rudland
British Journal of Cancer 114, 1101-1108
Research | 27 January 2015 | open

Nuclear osteopontin-c is a prognostic breast cancer marker
- K Zduniak
- , P Ziolkowski
- , C Ahlin
- , A Agrawal
- , S Agrawal
- , C Blomqvist
- , M-L Fjällskog
- & G F Weber
British Journal of Cancer 112, 729-738
Research | 08 May 2014 | open

Osteopontin deficiency aggravates hepatic injury induced by ischemia–reperfusion in mice
- S Patouraux
- , D Rousseau
- , A Rubio
- , S Bonnafous
- , V J Lavallard
- , J Lauron
- , M-C Saint-Paul
- , B Bailly-Maitre
- , A Tran
- , D Crenesse
- & P Gual
Cell Death & Disease 5, e1208
Research | 28 January 2014 | open

Suppression of tumour growth by orally administered osteopontin is accompanied by alterations in tumour blood vessels
- S R Rittling
- , P L Wejse
- , K Yagiz
- , G A Warot
- & T Hui
British Journal of Cancer 110, 1269-1277

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News and Comment

Research Highlights | 22 March 2018

Basic research: Visceral adipose tissue regulates cardiac ageing
- Alexandra Le Bras
Nature Reviews Cardiology 15, 254-255
Correspondence | 31 August 2017

Plasma thrombin-cleaved osteopontin as a potential biomarker of acute atherothrombotic ischemic stroke: comments on data sparsity
- Erfan Ayubi
- & Saeid Safiri
Hypertension Research 40, 944
Research Highlights | 10 July 2017

Haematopoiesis: Osteopontin skews lymphoid–myeloid balance

Intracellular and secreted isoforms of osteopontin differentially regulate myeloid progenitors and differentiated lymphoid cells, respectively, through pro- and anti-apoptotic effects.
- Kirsty Minton
Nature Reviews Immunology 17, 466-467
Research Highlights | 23 November 2010

Biomarkers: Osteopontin to determine response to parathyroid hormone therapy?
- Linda Koch
Nature Reviews Endocrinology 6, 653

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