Osteoimmunology

Osteoimmunology is the study of how the immune and skeletal systems interact.

Latest Research and Reviews

  • Research | | open

    The role of innate T cell subsets in the pathogenesis of spondyloarthritis (SpA) is not well understood. Here, the authors examine the role of invariant natural killer T (iNKT) and γδ-T cells in SpA and show that disease-derived iNKT and γδ-T cells have unique and Th17-skewed phenotype and gene expression profiles within inflamed joints.

    • Koen Venken
    • , Peggy Jacques
    • , Céline Mortier
    • , Mark E. Labadia
    • , Tine Decruy
    • , Julie Coudenys
    • , Kathleen Hoyt
    • , Anita L. Wayne
    • , Robert Hughes
    • , Michael Turner
    • , Sofie Van Gassen
    • , Liesbet Martens
    • , Dustin Smith
    • , Christian Harcken
    • , Joseph Wahle
    • , Chao-Ting Wang
    • , Eveline Verheugen
    • , Nadia Schryvers
    • , Gaëlle Varkas
    • , Heleen Cypers
    • , Ruth Wittoek
    • , Yves Piette
    • , Lieve Gyselbrecht
    • , Serge Van Calenbergh
    • , Filip Van den Bosch
    • , Yvan Saeys
    • , Gerald Nabozny
    •  & Dirk Elewaut
  • Research | | open

    B cells contribute to rheumatoid arthritis pathogenesis and bone erosion, but the underlying mechanisms are still unclear. Here the authors show, using mouse models and patient tissues, that B cells directly inhibit osteoblast differentiation by producing CCL3 and TNF, thereby providing a potentially new direction for arthritis therapy.

    • Wen Sun
    • , Nida Meednu
    • , Alexander Rosenberg
    • , Javier Rangel-Moreno
    • , Victor Wang
    • , Jason Glanzman
    • , Teresa Owen
    • , Xichao Zhou
    • , Hengwei Zhang
    • , Brendan F. Boyce
    • , Jennifer H. Anolik
    •  & Lianping Xing
  • Research | | open

    Inflammation can promote cartilage degradation by inducing matrix-degrading enzymes via NF-κB. Here the authors uncover reciprocal inhibition of Yap/Taz and NF-κB signaling though TAK1, and identify Yap activity as critical for maintenance of cartilage integrity in a mouse model of osteoarthritis.

    • Yujie Deng
    • , Jinqiu Lu
    • , Wenling Li
    • , Ailing Wu
    • , Xu Zhang
    • , Wenxue Tong
    • , Kiwai Kevin Ho
    • , Ling Qin
    • , Hai Song
    •  & Kinglun Kingston Mak
  • Research | | open

    Osteoclasts mediate bone disruption in a number of degenerative bone diseases. Here, the authors show that miR-182 regulates osteoclastogenesis via PKR and IFN-beta signaling, is correlated with rheumatoid arthritis, and that its ablation or inhibition is protective against bone erosion in mouse models of osteoporosis or inflammatory arthritis.

    • Kazuki Inoue
    • , Zhonghao Deng
    • , Yufan Chen
    • , Eugenia Giannopoulou
    • , Ren Xu
    • , Shiaoching Gong
    • , Matthew B. Greenblatt
    • , Lingegowda S. Mangala
    • , Gabriel Lopez-Berestein
    • , David G. Kirsch
    • , Anil K. Sood
    • , Liang Zhao
    •  & Baohong Zhao

News and Comment