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The Mannich reaction proceeds by functionalization of C(sp3)-H bonds alpha to carbonyls. Here, the authors suppress the Mannich reactivity of acetophenones in presence of a manganese catalyst and obtain valuable o-aminoalkylacetophenones and isoindolines via C(sp2)-H functionalization with imines.
Catalysis involving Au(I)/Au(III) cycles are notoriously hampered by the reluctance of Au(I) towards oxidative addition. Here, the authors show that an hemilabile bidentate ligand promotes oxidative addition of aryl halides to Au(I) and the catalytic formation of biaryl coupling products.
The unique properties of ferrocene-containing compounds make them useful for treating many diseases. The most notable drug candidates — the antimalarial ferroquine and the anticancer agent ferrocifen — have been studied for more than two decades but have not yet met clinical approval. This Review describes the design of ferrocene-containing drugs as well as the challenges faced in bringing them into clinical use.
Mathematically modelling metal–ligand bonding in late transition-metal complexes has been an important tool in catalyst development — although lacking for early transition metals such as Cr and Ti. Now, a simple method for measuring ligand donor properties promises to elevate high-valent early transition metal catalysis to the same level.
Our understanding of actinide chemistry lags behind that of the rest of the periodic table. A collection of articles in this issue highlights recent progress featuring uranium(VI) dianions bearing four U–N multiple bonds, berkelium(IV) stabilized in solution and delocalization of 5f electrons in a plutonium material.