Organ transplantation

Organ transplantation is a procedure in which a functional, intact organ is transferred from one individual to another. The organ is then functional in the recipient. This type of transplantation can occur between individuals of the same species or between individuals of different species.

Latest Research and Reviews

  • Research | | open

    Organs from donors with transmissible viral infections, such as hepatitis C virus (HCV), are not offered for transplantation due to a high risk of transmission. Here, Galasso et al. develop a method for treatment of HCV-infected human donor lungs that is safe and prevents HCV transmission in the pig model.

    • Marcos Galasso
    • , Jordan J. Feld
    • , Yui Watanabe
    • , Mauricio Pipkin
    • , Cara Summers
    • , Aadil Ali
    • , Robert Qaqish
    • , Manyin Chen
    • , Rafaela V. P. Ribeiro
    • , Khaled Ramadan
    • , Layla Pires
    • , Vanderlei S. Bagnato
    • , Cristina Kurachi
    • , Vera Cherepanov
    • , Gray Moonen
    • , Anajara Gazzalle
    • , Thomas K. Waddell
    • , Mingyao Liu
    • , Shaf Keshavjee
    • , Brian C. Wilson
    • , Atul Humar
    •  & Marcelo Cypel
  • Reviews |

    The complement system has a key role in inflammatory reactions that occur before, during and after transplantation. Here, the authors discuss this role and highlight current and future strategies to regulate complement activation and potentially improve outcomes in kidney transplantation.

    • Ali-Reza Biglarnia
    • , Markus Huber-Lang
    • , Camilla Mohlin
    • , Kristina N. Ekdahl
    •  & Bo Nilsson
  • Protocols |

    This protocol describes a pig model in which lungs are transplanted into recipients who are subsequently monitored for 3 d after surgery to study ischemia reperfusion injury and early graft function.

    • Andrea Mariscal
    • , Lindsay Caldarone
    • , Jussi Tikkanen
    • , Daisuke Nakajima
    • , Manyin Chen
    • , Jonathan Yeung
    • , Marcelo Cypel
    • , Mingyao Liu
    •  & Shaf Keshavjee
    Nature Protocols 13, 1814-1828
  • Reviews |

    Improved understanding of HLAs together with advances in HLA typing and antibody detection techniques have enabled transplantation of sensitized patients. Here, the authors discuss these advances as well as novel approaches to desensitization, immunomodulation and tolerance induction.

    • Robert A. Montgomery
    • , Vasishta S. Tatapudi
    • , Mary S. Leffell
    •  & Andrea A. Zachary

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