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Oncostatin M is a secreted cytokine, and is related to leukaemia inhibitory factor. Oncostatin M functions in differentiation and development of various cell lineages, cell proliferation, and haematopoiesis. The transmembrane receptor for Oncostatin M on responding cells is a heterodimer between the glycoprotein gp130 and either CD118/LIFR or OSMR.
This Review considers the key roles of the IL-6 cytokine family in regulating innate and adaptive immunity, as well as other physiological responses. The authors highlight the potential of targeting IL-6 family members to treat inflammatory diseases and cancer.
