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The olfactory bulb is the part of the central nervous system that receives olfactory information from the olfactory receptor neurons and relays the information to subcortical and cortical areas of the olfactory system.
Cholinergic neurons innervate multiple layers in the main olfactory bulb but the precise circuitry of this input is not known. Here the authors show that VGLUT3+ cholinergic neurons selectively innervate deep short axon cells in specific layers and elicit robust monosynaptic GABAergic and nicotinic postsynaptic currents.
A study now shows that granule cells deep in the olfactory bulb exhibit wildly different response dynamics depending on behavioral state, suggesting they could configure network changes across behavioral states.
Although projections from the insect antennal lobe to the mushroom body are probabilistic, those to the lateral horn are stereotyped, suggesting an interplay of preconfigured and plastic circuits in olfactory processing.