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The olfactory bulb is the part of the central nervous system that receives olfactory information from the olfactory receptor neurons and relays the information to subcortical and cortical areas of the olfactory system.
The authors show that, unlike the consolidation and refinement of excitatory connections observed during sensory map formation, a dramatic broadening of patterned activation domains, connectivity, and tuning occurs in interneurons in the olfactory bulb. This developmental expansion is sensitive to activity manipulations and may reveal general principles of interneuron network development.
The authors show that a normative approach to olfaction, Bayesian inference, reproduces much of the anatomy, physiology and behavior seen in real organisms. The model provides insight into how the olfactory system demixes odors, and, by extension, how other sensory systems extract relevant information from activity in peripheral organs.
A study now shows that granule cells deep in the olfactory bulb exhibit wildly different response dynamics depending on behavioral state, suggesting they could configure network changes across behavioral states.
Although projections from the insect antennal lobe to the mushroom body are probabilistic, those to the lateral horn are stereotyped, suggesting an interplay of preconfigured and plastic circuits in olfactory processing.